FireVoxel Build 329 is released.

1. Started a new DLL project: FvxANN, It is explicit load DLL and is optional during distribution. This means FireVoxel would still work but certain functionalities will be missing. FvxANN interfaces with TorchLib C++ from FAIR.

2. Implemented TSL automatic extraction from DICOM files {SERIES ,PROTOCOL}. 
User has to specify the Units to load.

3. TSL dynamic dimension is fully implemented now.


4.Enabled  FVX file support (Load\Save) for TSL dimension.

5. File filter changed to "4D Image (*.time)"

6. T1rho implemented the mono-exponential model.

7. Implemented completely new Dynamic Modelling Results dialog box:

8. Global optimization outputs now "guaranteed interval of optimal parameters".  In the parametric modelling dialog there are 2 new columns reflecting that info.







9. Parametric results can be copied to Excel via clipboard.




10. In Dynamic Processing dialog box, if no Output Parameters were checked, after warning the system returns back to the dialog instead of quitting it.

11. Parametric model processing verification dialog pops up only in {ROI,ALLROI} modes, but not the voxelwise modes.

12. "Normalize by ROI" : Koefficient typo fixed.
13. Fixed the crash when  VROI is present but unselected, with right mouse button drag.

14.  Fixed crash when executing Cancel Load VROI - Vector -> Load VROI -> Cancel. 

15. ROI>Morphology changed menu to {Peel,Grow} 
16. VROI:  rectangle diagonals are smooth now using Gdiplus. 
17. Parametric modelling dialog: removed the 2nd redundant button now. Also the text on the button now depends on what was selected and will be processed.

18.Provided the Echo time - >TSL conversion for this dataset, as you

suggested. The new function is under MainMenu>4D Processing>Dynamic Dimension Support

Build 328 is released.

1. Removed the "flickering cursor" problem when passing over the polyline or spline.
2. Removed the AllViewsRedraw from CDrawPoly::DeletePoint which was causing a recursive call and crash.
3. Fixed MagTrace defect when MainEntity was selected with the Spline, so while the anchors were visible it was not possible to move them.
4. Fixed a defect while moving curve and splines, when the LButtonUp and RButtonUp events are missing some time which resulted in curve's anchors wildly jumping.
5. Code work on the legacy CDrawTool class, MagTraceTool and PolyTool subclasses
6. Enabled VROIs and Landmarks to have individual colors. The color panel in VROI dialog is now working.
 7. Extensive code optimization in function :  AlViewsRedraw, FV_EndWaitCursor, NonZero,IsZero, NonEqual, IsEqual.

Build 327 is released.

1. Restored the SAT\VAT segmentation functionality on the entire volume.
2. Provided multiple additional variants for the Abdominal CT fat workflow
3. Fixed the intermittent crash when removing the layers cause by Undo\Redo.
4. New morphological algorithm "Close broken contours and fill 2D" and a corresponding menu item under ROI>Morphology.
5.  Multi-slice projections (such as MaxIP) and FilmView are mutually exclusive now with the corresponding switches disabled
6. VoumeInfo dialog: Copy To Clipboard : fixed defect when only visible items were copied.
7. Vector Rasterize function:  added the Undo
8. Layer control dialog:  changed the "Save RAW" to "Save Image".
9. Main menu>File  change "Load\Save FireVoxel document" to "Load\\Save document"
10. Updated the SetProjection dialog by removing unused entries, adding Minimal Intensity projection.

Build 326 is released.

1. Complete rework of the Whole Fat segmentation from Abdominal CT
   a) Gross problems of Pelvis, Diaphragm, and arms were resolved
   b) New algorithm to separate fat and muscle when the fat and muscles signal intervals
    overlap substantially.
2. New function and UI menu item to segment whole fat on a single selected slice.
3. New function and UI menu item to segment whole fat and with the abdominal cavity ROI present
    to perform SAT\VAT segmentation.
4. Coding update: for all relevant Document::AllViewsRedraw now includes the Layer Control Dialog update.

FireVoxel Build 325 is released.

1. FLEXR-Motion Correction: implemented option to consider first N timepoints static (without motion).  Often there is a very little contrast in the initial timepoints, so registration individually is challenging.
2. Replaced "Save RAW" menu and dialog items to "Save Image".
3.Implemented Initial Undo\Redo functionality to cover Paintbrush painting\erase. Undo\Redo buttons in the main toolbar.
4. Implemented the toolbar Undo\Redo button status  update (graying) depending on whether any Undo\Redo records are available.
5. Added keyboard accelerators "Ctrl+Z" and "Ctrl+Y" for Undo\Redo respectively
6. Added unit test for Visceral\Subcutaneous fat segmentation functionality from Abdominal CT.

Build 324 is released.

1. Implemented EdgeWave variant when starting Peel voxels are either External Surface only

or custom provided from the calling function.

2. Implemented the 2D Structure Graph  technology.
This converts any 2D ROI into the planar graph.

3. Implemented EdgeWave variant when the custom Start Surface is provided. Unified that code the External Surface code.

4. Implemented the Subcurtaneous\Visceral FAT separation algorithms. Fully automatic. Initial accuracy is under 2% comparing to manually generated ground truth.

5. Implemented a parameter dialog for the VFAT\SFAT separation

6. Included into the distribution package all Microsoft DLLs corresponding to a redistributable. This allows to avoid missing DLLs issue due to discrepancy between the Visual Studio update and redistributable download site.




7. Spawned previously reused RoiStats4D dialog into a separate DynamicExperimentResults dialog so it can be better customized without affecting other functionalities.

8. Implemented a workflow for Subcutaneous and Visceral abdominal fat separation. Provided QuickStart documentation.

Build 323 is released.
1. Fixed defect in Paintbrush over CT-abdomina volume (Zero transform message was popping up while changing paintbrush radius.
2. FLEXR registration: enabled the scenario when Source and/or Target are binary images (1 bpv) optionally overlayed by a ROI.
3. FLEXR implemented a proper resulting volume type conversion when "Output Real" version is ON\OFF. This included conversion to the original image type if OutputReal=FALSE.
4. Implemented "CT Abdomen Whole FAT segmentation" function. This includes a custom dialog.
This is under Worflows>CT Abdominal Fat segmentation>Segment Whole Fat mask

Build 322 is released.

1. FLEXR: Implemented MicroSegmentation local similarity measure which performs Otsu thresholding for each keypoint vicinity thus providing flexible registration. Results are most identical with Mutual Information but do not have NumBin parameter.
2. FLEXR including Dialog:  implemented Output Target masking options {NONE,Zero,VOID} on how the Target mask is applied when the Source(Moving) frame is resliced.
3. FLEXR: implemented experimental OptiMap local registration match measure.
4. Detect Body Mask updated the algorithm and exposed basic dialog box under MainMenu>Segment>Detect Body Mask
5. Implemented an initial variant of the BiCal batch with the optional output to {Dicom,Dicom Compressed,Nifti }
 
 6. Implemented customizable overlay grid on original Projections only. It is under Main Menu>Display>Display Grid


 

Build 321A is released.
Corrected defect in "Load RAW Folder" UI setting which was reset.

Build 321 is released.

1. Speed optimization of Dot Vector Product function (since it was 50% of total FLEXR time).
It is used widely throughout FVX including BiCal.
2. FLEXR :Guassian RBF matrix construction (fully dominates time):  separate the bottleneck into
a single MatrixLineConvolution and minor optimization of it
3.  GRBF deformable field:  optimization matrix calculation (at least 10000x10000 - 30000x30000). Noticed the sparsity of the underlying calculation and devised a variant based on skipping negligible values (1e-16) with x15 memory and speed improvement.
4. GRBF final field calculation:  separable  exponential term exp(-hypot3(x,y,z)) it was possible to pre-calculate the tables once for each axis for x4 speedup.
5. FLEXR-3D: When the Source Mask is supplied, in final Reslicing clip Source using Source Mask with VOIDVOX. This helped to uncover some deficiencies in COPD Lund Registration.
6. FLEXR: re-implemented new logic to handle cases with\without the Source Mask. New approach to ROI padding = {Displacement Padding+MeasurePadding}.
7. FLEXR: Removed "Inflate ROI" parameter from the dialog and internal processing.
8. FLEXR GRBF: Substantially decreased memory requirements for optimization matrices.
9. FLEXR GRBF: fixed the defect when the lower part of the symmetric matrix was not constructed.
10. FLEXR:  Edge Keypoint generation: added Nlimit parameter (~10,000 for neck) to select strongest keypoints. This allows specify grid of any density.  There was no substantail improvement in the Neck MI, perhaps sparse field regularity is critical.
11. FLEXR dialog box:  implemented Combo (dropdown) box for selecting Transform Type.
12.FLEXR: Implemented NW  Sparse-to-Dense interpolation scheme (from EpicFlow) paper. It is very fast and with good (not the top) accuracy.
13. FLEXR dialog:  removed option for the Gradient Norm. Now it is done automatically.
14. FLEXR-MC:  Output volume is now displayed with the same Window Center\Width as the original
15. FLEXR: Implemented option to display  Keypoints after the completion.  This is a new checkbox option in FLEXR dialog box.
16.  FLEXR: MST (minimal span tree) is calculated once for both Forward and Backward (symmetry) run.
17. FLEXR:MST: calculation now take next to 0 memory.
18. FLEXR: Dialog: added option for the Regular Keypoint Grid.
19. FLEXR (incl Dialog):  Added  new Similarity Measure = Signal Difference.
20: FLEXR: Implemented Mutual Info\MI-NORM local similarity measures and corresponding Dialog items.
21. File>Open Image (multiple files): corrected various small defects, including saving the file name instead of path to FVX config file.
22. FLEXR: further optimized speed of NW transform and Local Mutual Info.

Build 320 is released.

1. FLEXR-MC: dialog\Test defect fix.
2. FLEXR-MC:   GRBF transform progress message defect fix.
3. MainMenu>Measurements>Two Volume RMSD : corrected so in case of 4D volume the Current Timepoints are compared.
4. TPS transofrm: fixed a small defect in optimization matrix construction.
5. GRBF tranfrorm: fixed defect in the final field interpolation.
6. Main Menu>Segmentation>Feature Points : fixed crash defect when called on a selected timepoint of the 4D volume
7. Main Menu>Measurement>RMSD : fixed crash defect when a single layer and present, outputs warning "2 non-roi operands are required".
8. FLEXR-MC (motion correction) dialog box:  Added a "Serial" algorithm option
9. FLEXR-MC dialog box:  added option to Correct Gross Motion only, when user specifies only Gross Motion timepoints and deformation field is re-used for in-between timepoints.
10. FLEXR-MC dialog: Added the the Ensemble 4D dynamic algorithm option (Averages all registered frames to make new target at each step).
11.  FLeXR-MC dialog : Added Use SVD option.
12. Corrected *.TIME\MIDAS load to accept the {PT,PET} as modality (only PT earlier)
13. NIFTI\TIME file load: removed reliance on the Byte Per Voxel tag in the TIME header. This was leading to the confusion, such as float-32.  Additional feature the NIFTI files of different byte type can be loaded as 4D.
14. Main Menu>4D Processing:  added functions to measure Cross Frame Mutual Info over the ROI for 4D volume (both MI and MINORM). This is a helper function for evaluating the quality of Motion Correction
15. Volume>Crop specified dynamic points : corrected so the final cropped redraw is done for all layers.

Build 319 is released.

1. Re-ran the Neck registration example using new Tomasi feature detector.
Comparison of the largest displacement between t1 and t38 shows good registration (red over green).

2

2. Performance optimization in "Voxel Context" similarity measure.
3. Change the Parallel design within the "Voxel Context" similarity measure to reduce the memory bandwidth.
4. Implemented ABT subtest for FLEXR Neck Motion correction.
5. Optimized the VolumeConvolute3D( PDOUBLE ) function for speed. Checked presence of VOID voxels and simplified calculation without them.
6. FLEXRMC dialog box: removed irrelevant Similarity Measure options, leaving only {VoxelContext, Xcorr, URAL}
7. NIFTI Save:  implemented cal_min\cal_max fields save (Window Center\Width), so it can be
properly opened by other software (f.e. Mango).
8. Fixed the defect so the 3D Crosshair Cursor only getting synchronized when the UI is in the "Select Mode". Otherwise it was repositioning when LMB click during {Zoom,WindowLevel,etc}
9. Fixed precision problems with 3D Crosshair cursor.
10. UI Interface: introduced new items  under Main Menu>Registration :
       a) FLEXR-MC (motion correction)
       b) FLEXR-3D (general deformable registration).
11. NainMenu>Workflows: introduced the CT lung workflow item. This only include the FLEXR3D item with the default parameters suitable for COPD registration project.
12. Layer Control dialog is fully resizable now by pulling any of the 4 corners.
13. MainMenu>File>Open RAW Image:  any number of files can be selected for simultaneous load.
14. MainMenu>File>Open  FireVoxel document : any number of files can be selected for simultaneous load.
15. When the last window of the current document is about to close, the Save option is offered.
16. Implemented ROI Multi-Layer averaging operation : under Main Menu>Roi>Average ROI Layers

Build 318 is released.

1. Consolidated all the variants of the Foerstner feature detector and removed related redundancies.
2. Changed BiCal UI so the corrected volume is always displayed, additionally\optionally overlaid by the bias field.
3. BiCal dialog :  Background Preserve\Morph feature is activated if AirMorphRad<1000. Otherwise it is skipped. Reset the default dialog parameter to 1000.
4. Full re-engineering of the Feature Point detection functionality.  UI menu changed to include Tomasi Feature detector.
5. Developed  a novel Basic Feature Detector method similar to structure tensor logic but without taking the gradient - working directly with the signal values. One advantage over the Structure Tensor method is that the Detector Threshold values can be expressed in Signal values.
5a. Exposed both Tomasi and Basic feature detectors through UI.
6. Implemented generic dialog box Specify Three Double values. This allows some common task to reduce burden on the User to go through several dialogs.
7. Exposed a Threshold parameter for Feature Point detectors and used the Specify Three Doubles dialog for the Feature point detectors.
8. Tensor Structure feature response: Replaced Separable (non-isotropic) Gaussian smooth filter with the Isotropic spherical filter.
9. Using the isotropic Tomasi feature detector resulted in Lund registration substantial improvement to:  Average\Median\Max error of   1.01\0.90\3.25 mm.
10. When loading NIFTI integer volume, check if there are only 2 signal values are present [0,Sig]. In that case offer User an option to load as Binary ROI.
11. Implemented VROI rasterization from Vector Menu and toolbar button
12. Provided a combined menu for ROI>{Clear Inside [Z0,Z1] interval,Clear Outside [Z0,Z1]}.

Build 317A is released.
1. FLEXR : enabled the option for the GRBF interpolation.
2. Code prunning to remove unused\secondary FLEXR variants.
3. Re-enabled the "Preserve FOV" option during the Volume Transform.

Build 317 is released.

1. Fixed defect and provide x8 speed up for Voxel Context similarity measure.
2. Fixed defect while cloning the dynamic volumes.  For some reason the DICOM header of the 0th timepoint was cloned over the rest. So now it  uses all timepoint headers appropriately. This defect occurred  while doing motion correction on the DTI  5-slice kidney mosaic.
3. Fixed the defect in KSFAPv2 procedure. This was due to an earlier upgrade of the Ridge detection function to REAL output.
4. DICOM Open dialog box: corrected selection  behavior of the "Copy" and "Delete" buttons.  Now the checked items are considered for the whole tree, not just the subtree of the selected item.
5. Removing redundant records during the DICOM tree construction: was slow on the large collectrons (32,000 files).  Optimized and sped up from 16 sec to 2 sec and added the Progress indicator.
6. Modified the PR_SendMessageInterval so when (DoProgress==false) there is no action and unwanted hourglass would not appear
7. Remove the "Double Pass" option from the BiCal Research dialog.
8. FVX ParSVD :  with Epsilon precision:  change the Eps to be a relative to the norm of the Right Hand Vector.
9. Conjugate Gradients for Linear Equations: made corrections when NAND happens within the main iteration loop
10. Restored the AVX2-base Vector Dot Product function for about 20% speed-up in BiCal. It appears however that the AVX2 slightly looses precision
11. Argazi (Texture) Edge detector : fixed defects in determining the direction of the gradient vector. (defects were in the ORANGE structure initialization).
12. ARGAZI Image gradient: updated normalization based on the radius and vicinity weights so that the value of the gradient closely matches the derivative taken from the voxel values.
13. Introduce advanced BiCal variant  BiCal# base on the Gradient detection only. This skips the Edge detection and Constrained Smoothing stage.  Number of the UI parameters will be removed
14. Removed basic BiCal dialog. Old BiCal+ menu item and dialog where optimized and rename a new basic BiCal.  New BiCal# menu item and dialog were introduced.
15. Complete new ABT: BiCal subtest including {Brain,Breast,Abdomen} and synthetic chessboard images overlaid with  exp(k*X),exp(k*Y),exp(k*Z) fields for precise reconstruction.

Build 315 is released

1. Implemented the initial variant of the FLEXR - Motion Correction dialog box.






































2. Implemented an initial variant of the FLEXR- Motion Correction wrapper code. Tested in on 10-timepoints Neck DCE-MRI.
3.  Fixed one of the memory leak defect in FLEXR-MC.
4. Parallelized the TPS parameter calculation in FLEXR-SYMM variant
5. Added a "Output : Real Voxels" option in the FLEXR-MC dialog.
6. Fixed the Dynamic Dimension defect when loading DWI images and selecting the "Selected and Checked" DICOM load.
7. Replaced DICOM load choice with "Selected only" and "Checked only".

Build 314 is released.

1. Implemented a module for synthetic testing off some Dynamic Models. Tested the M49 DCE Reference Region model and fixed the calculation defect.  Residual cut by half.

2. Enable the 3D Raster Paintbrush.  Added the correspoding option to Paintbrush Dialog.


3.  When the "Synchronized 3D Cursor" UI option is enabled, it now works when the Paintbrush is applied.








4. Implemented far more precise (when K->0) formula  Func[i] = Integ<G(u)*exp(-K(X[i]-u))du> 
This affects many models using this convolution, resulting in higher precision for cases when K->0

5.  Fixed 32-bit buffer size overflow in VA_VolGetAll() function.
6.  Added Progress bar to  Layer Arithmetic operations.

Build 313A is released.
1. Model 49 (DCE Reference Region): corrected crash in voxel-wise processing.
2. . Model 49 (DCE Reference Region): added ABT subtest

FireVoxel Build 313 is released.

1. Imlemented Model #49: MR 2 compartment Reference Region model (Yankeelov 2005)
2. RoiStats4D dialog: displaying the curve without offset now to avoid visual confusion.
3. UI:  Re-enabled BiCal option to output the Bias field
4.  Verified that Model #49 with the Identity test, i.e. running on Reference Region returns RR {Ktrans,Ve} with high precision.
5. Open DICOM dialog:  corrected the defect when Copy operation and there are several source files
in different source folders but with the same file title resulting in overwritten files.
6. Fixed a typo error in the determining DICOM frame exact acquisition time.
7. Implemented Volume>Voxel Value Conversion> Change Transparent Signal.
8. Model #31 (MRTM2) fixed defect when the output Parametric Map color scheme was not initialized.
9. Fixed defect in 2-Volume Max Difference function
10.  Removed redundant HCT correction from some models

11. Added ability to add\modify the DICOM tags  {TE,TR,FA}


12. Fixed the defect in Dynamic Experiment dialog: when the IF and Tissue Concentration dialogs appear then {TE,TR,FA} fields are filled properly from the Volume DICOM tags

13. Enabled the FWTE calculation of the Concentration->Signal so it can be used in Modelling.

14. Extended the "Edit DiCOM tags" functionality to optionally Edit all the timepoints at once.














15. Volume Value Conversion dialog (after DICOM load): change layout to make functionality more clear so Add\Mul are applied ONLY when loading as INTEGER.











16. Corrected the imperfect shape of the Raster Paintbrush at small radii.

Build 312 is released.

1. N4explorer: corrected default parameter ranges. Report now display the elapsed time for the entire optimization.
2. OverlapError calculation in N4explorer: changed the ThresholdDelta=>1e-3 to make it much faster.
3. Speed optimization from Xcorrelation measure calculation  in the context of the discrete registration (x3 speed up achieved).
4. FLEXR deformable registration:  integrated the new XCORR measure and achieved a very good result on COPD Lung registration with :  1.32\1.24\4 mm.
5. Speed optimization of the XCORR measure on the very large volumes.
6. Incorporated XCORR measure into the FLEXR deformable registration for 1.2 mm accuracy on Lung COPD data
7. FLEXR:  insured the "Identity Test" with high precision, i.e. registering the volume to itself and checking high precision with Average Err < 1e-5.

9.a higher precision in Lung registration, now at Average \Median = 0.98\0.80 mm.
Also, even better visual quality on the Neck registration:
10. Doublechecked the legacy interpolation modules and finally cleared it to be perfectly fine.
11. Extended the *.time functionality to support VFA dynamic dimension.
12. Various TPS transform optimizations.
13.  In "TAC: Curve View" dialog fixed defect so the Tissue Properties are transferred properly for the Input Functions.

Build 311 is released.

1. Fixed memory defect in (freeing PDICOMREC)
CVol::CreateDynCrdFromFF , FV_LoadDicomFileSet

2.  Implemented 99% automatic MRI  Neck segmentation algorithm for the Neck registration project.





3. Implemented 1st variant of Neck MR registration.
4.  Added the Volume>Signal Value Conversion>Scale To Interval function

5. Fixed defect in retrieving the VROI coordinates in Seed functions (was adding extra slice).

6. Implemented ZNCC (Zero Normalized Cross Correlation) measure in the ReMIND deformable registration code.  This is for Neck Motion Correction project.  Result seems to be visually as good as the original SSC metric.

7. Performed comparison of   ABS(ZNCC)  vs.  Max(0,ZNCC) similarity measure

7. Finetuned the ReMIND:XCORR variant of the deformable registration on the COPD lung images. It reaches good 2/0.9 mm average/median error.
8. Implemented the OE (Overlap Error) measure with the specified precision of threshold so it could work on REAL volumes.
9. Nonuniformity measurement functions:  added the automatic CopyToClipboard feature.
10. Fixed DICOM load defect when 8-bit volume with Rescale\Intercept was present (GE-CT)
11. Fixed crash in Landmark Registration (Cloning of the DICOM header when number of target slices exceeds source).

Build 310 is released.

1. OpenDicom dialog box:  fixed defect in "Show Compatible Volumes" functionality.
2. OpenDICOM dialog box: added a function (button) "Uncheck All" - removes all checks from All
items
3. Developed a 3-choice customizable dialog for a more transparent UI.
4. Eliminated the performance inefficiency in Zooming\Affine functionality. All zooming functions are impacted and the most visibly the FilmView.
5. Major rework of the OpenDICOM dialog box. Separating the Selection and Loading functionality.  New ability to load arbitrary combinations of compatible Series.
6. Implemented "Average Nonuniformity Measurement" for all opened documents.

FireVoxel Build 309A is released.

1. OpenDICOM dialog box: Impemented he "Dicom Tag Difference" tool that detects all different DICOM tags for 2 selected files and copies the aggregate result to the clipboard.

2. DICOMREC structure modification to include additional BOLUS attributes.

3. Incorporated the Bolus attributes into DICOM 4D Volume construction logic so the CIR31 series 98 are properly separated now.




4.  OpenDicom dialog new feature:  all composite SERIES corresponding to dynamic
Volumes With Contrast are now marked with the red frame around the SL or VL icon.

5. BACKSPACE button is now working as a DELETE button when not the single Polyline is selected.

6. N4explorer: Fixed  typo errors in displaying the result.

BICAL paper evaluation:Suggested parameters accessible through BiCal+ functionality:

Abdominal GRASP case

head BPD  7T

Breast FAT\FGT case

Build 309 is released.

1. Corrected crash defect in Nonuniformity Measurement.
2. DICOM load: fixed defect in logic combining separate SERIES into a 4D Volume.  Some Volumes
were incorrectly assembled
3. BiCal: Corrected  defect in core BiCal procedure (edgemap reuse in iteration).
4. BiCal: fixed the defect with isotropic volumes DoublePass
5. Fixed the crash in Noise calculation function on REAL images
6. BiCal: enabled REAL input images.
7. Fixed N4explorer  parameter setting for Noise.
8. NIFTI load: fixed defect loading single NIFTI 4D file.
9. Further correction in DICOM logic of parsing the 4D files.
10. Fixed a defect in loading of b-values from SIEMENS DICOM file.

Build 308 is released.

1. DICOM Tags for Diffusion: fixed the B-factor (B-value) loading for the following Philips models:
{ Ingenia, Achieva, Multiva, Intera }
2.Bical now outputs REAL type image as the result of the processing.
3. BicalResearch dialog: Implemented an additional option "DoublePass" which further improves the results.

4. BiCalResearch dialog: redesign of several fields - now includes the AirThreshold in Noise units, a separate Baackground panel.

5. Streamlined the BicalResearch dialog box.  Change the AirLevel and EdgeLevel parameters to
be in Noise units to make it more robust across the images.

6. Combine two Non-uniformity measurement items into one under the MainMenu>Nonuniformity

7.  MainMenu>Transform>Rotate
Corrected several defects with the global parameter in the dialog.

Best parameters for processing the GRASP\Abdominal case, from BicalResearch dialog:

Build 307 is released.

1. BiCal: Fixed the Edge detector threshold defect
2. BiCal Research dialog: Exposed the  Edge Radius, Edge Threshold parameters.
3. BiCal Research dialog: Noise calculation is done automatically and that level is
displayed so the User can set Edge threshold based on noise units.
4. Bical Research dialog: introduced new Basis functions:
{Legendre,Chebyshev1,Chebyshev2, Regular Polynomial,Cosine}
5. BiCal research dialog: removed the "SVD tau" parameter.  "Background morph" parameter is now in (mm).
6. Fixed defect (crash) when during the Polyline drawing the User presses delete without pressing ESC first.
7. Enable the load of TIME\NIFTI   4D files.

FireVoxel Build 306 is released.

1. Implemented function to load all the FVX documents from the specified folder.
This is under the MainFrame>File> menu.

2. Removed a failing check for the presence of the VC++ 2019 Redistributable.
3. Added a voxelwise CJV calculation under the Nonuniformity>Measure menu.
4. Corrected the calculation of CJV measure according to B. paper.

5. Re-implemented N4-explorer tool with 5 optimization measures
{ roiaNU,robNU,CSM,blobCJV,voxCJV }
   a) Start application and File>Open FireVoxel Folder.
   b) Specify location of the folder, press OK.  All fvx files in that folder will be opened.
   c) Application will check if all documents have the same number of Active ROIs.
   d) Press MainMenu>Nonuniformity>N4 Explorer. Corresponding dialog will show up.
   Define the ranges for the optimization parameters. Set the constant parameters using the
   N4 parameter dialog box in the left lower corner.
   e) Optimization will run. Final dialog will show up. Each of 5 optimization results will be displayed   in the Info dialog and the same result will be copied to the clipboard.


6. BiCal Dialog: introduced the bool variable : "Output Foreground" that outputs the ROI mask for the foreground voxels used in BiCal calculation.

FireVoxel Build 305 is released.

1. BiCal optimization matrix construction: Further acceleration which becomes dominant at the higher degree of the field.
2. BiCal:  Removed a non-existent option for field in AIR from use interface, since there is only VOIDFIELD option is allowed in the Air.  BiCal research dialog box is simplified .
3. FireVoxel start-up:  added checks that VC++ Redistributable 2013 and 2019 are present.
4. Fixed the incorrect initial volume zooming position when loading a document (expressed in Debug version only)
5. MRTM2 (model #31):  added an Output parameter : RMSE/Average Signal.
6. MainMenu>Nonuniformity>Measure NU of two layers  added the CJV measure.
7. Added ABT subtest for MRTM2.
8. Fixed the issue with the negative field in the RoiStat3D dialog box. Implemented a custom
dialog field function for double precision floats with the user-specified precision (from 15 to 30 decimal positions).

Build 304D is released.

1. Added additional diagnostics for the Input\Output files presence during the N4 execution.
2. BiCal dialog: Changed the Subsample parameter to Processing Scale parameter [0.1,10]. Fixed the defects and tested. Note: now the larger number will slow down processing, smaller will speed up.
3. Substantial BiCal speedup when using Processing Scale = 0.5. On 7T brain a minor reduction in quality with NU raising from 0.051 -> 0.057
4. BiCal: Speedup in matrix construction

FireVoxel 304B is released

1. Modified the command line construction for the N4*.exe tool.

FireVoxel Build 304A is released.

1. Fixed defect in reporting the diagnostics message for the Windows system GetLastError() function.
2. Enable N4-ANTS to run on the Real volume (this also allows a direct N4 second pass on the same image).
3. Added an execution notification while N4 command line is running.
4. Performed optimizations so the BiCal single run reaches very close result to BiCal double run but without extra time or blurring of the double run.
5. MRTM2 model (#31) added the Relative Error output parameter

FireVoxel Build 304 is released.

1. Dynamic Experiment dialog:  implemented a model-specific Input Function panel naming. When model is changed a proper panel name {Input function, Reference Curve,...} are displayed.

2. Restored the "Process Single curve" from the main menu without the need to create a document.

3. Restored the MRTM2 model:

4.  Rotate Volume UI parameters are now remembered between the calls.

Build 303C is released.

1. Transform>Rotate and Create New : corrected the naming of the 1st layer.
2. Corrected the Defect in LayerControl:Save ALL.  Now the folder is allow to have a dash "-" in it.

FireVoxel Build 303B is released.

1. Transform>Rotate Ortho  : fixed the defect with the naming of the 1st layer.
2. Enabled the Progress bar inside the  Transform>Rotate Ortho
3. Added extra diagnostics to the intermittent Save All defect.

Build 303 is released.

1. Provided 5 research branches for FLEXR deformable registration algorithm. They all achieve
fairly good registration of about 1.5 mm, but further development is needed to match the state of
the art 0.9 mm on the COPD datasets.

2. Provided BiCal Research dialog with most internal parameters exposed.

Build 302 is released.

1. Model 17: IVIM-segmented:  removed the check for non-pysiological fitting parameters, so  no VOID voxels are generated.
2. Implemented a variant of LES-SVD solution that find solution of specified precision.
This greatly accelerates the Jacobi-based parallel solution.
3. Big acceleration in Flow field computation for RGBF.
4. Corrected the Flow field transform to produce an identical interpolated volume for the Identity transform.
5. Improved diagnostic messages for Layers with the different Resolution\Orientation from the Base Layer.
6. Implemented ABT-subtest:  Lung landmark-based registration using GRBF
7. Corrected algorithm for the specified precision LES-SVD solution.
8. Expanded Transfrom>MakeIsotropic function to include option for Target resolution with the dialog.
9. Transform>Rotate Volume:  now rotates the centers of the existing VROIs and approximates the resulting size of the VROIs.
10. Integration of the existing code for large deformation registration : project ReMIND
11. Optimization of the memory and speed for ReMIND.
12. GRBF Dense Field optimization: replace SVD with HouseholderQR for speed. Removed the initial Affine transform alignment,
13. Implemented Key (PET) model 48.
14. Implemented Input Function dispersion in Model 48 which can be used in other models.
15. Enabled MagTrace to work on Real Volumes.

FireVoxel Build 301 is released.


1. Fully parallelized the Foerstner Map calculation (for keypoints detection)
2. Corrected Jacobian map calculation for vector fields.
3. Corrected crash when calculating the EDT (Euclidian Distance Transform) in Parallel mode.
4. Corrected the MST optimization so the resulting displacement only resides in the areas
permitted by the Source ROI mask.
5. Processed a problematic case for Monkey->Reference registration.  Use Average (not PCA) to accumulate.  Use 3vox Rad in URAL gradients. Then following:

Pre-1

Post-1

6.  Expanded Tissue attribute structure to accommodate up 16 values.
7. Introduced FVX document v9.  Provided backward compatibility
for FVXv8.
8. Tissue Properties (such as T1 for ROI) are now save as part of the FVX file.
9. Eliminated legacy FDX_Text() dialog support,  Microsoft corrected the DDX_Text bug
for "double" fields.

FireVoxel Build 300 is released.

1. Implemented corrected Optimum Location calculation in the 3-D Euclidian Distance Transform.
2. Implemented capability for each Dynamic Model to restrict allowed Concentration Conversions to the specified subset.
3. Dialog Parametric Maps calculation:  presently selected Tissue and Input Function concentration conversions are displayed.

4. Dialog Layer Control: "Save ALL" functionality is implemented to Save ALL marked layers to the specified folder in specified RAW format.

FireVoxel Build 299 is released.

1.  Corrected FileExists function to work with files >2GB.
2. When loading the *.time file with TE info, the TE info should be in (sec) in *.time file.
At the same time the DICOM header stores that info in (ms), so the proper synchronization
was implemented.
3.  Implemented fully parallel algorithm for "Equlidian Distance Transform over Sampled Function" with the complexity O(n) where  n is the number of voxels. This is an important functional block inside larger Viterbi algorithm inside the Deformable Registration project.
4. Implemented new Model "3. Interleaved 2-state profile".

FireVoxel Build 298 is released.

1.  Fixed defect in MouseHolder segmentation: segmented subvolumes retain the 4D attributes of the original 4D Volume.
2. Fixed general defect:  when 4D volume with dynamic dimension other than time is transformed, the dynamic coordinates of the transformed volume are now correctly preserved.

FireVoxel Build 297 is released.

1. Coded an initial variant of the FLEXR-AutoWarp function.

2. New easy and effective scenario for lung CT segmentation. EdgeWave with the seed, followed up by the F7 (contour fill function). Later on: make a standalone one-step function, with the simple dialog box, option to separate the L\R lungs, and possibly fully auto without specifying the seed.

3. Extended the document comparison function to include the Vrois comparison, with diagnostics.

4. Cleared up ABT subtest for the Foerstner landmarks. Extended Foerstner landmark detection to volumes including ROIs. Included lung+ROI Foerstner landmark detection into ABT.

5. Fixed the defect inside the recently optimized RoiGetNumberOfVoxels function.

6.  Fixed defects inside the SegmentMouseHolder function.
7.  SegmentMouseHolder function:  all output segmented subvolumes are identical size now.
8. Added ABT facility to verify several (all) opened documents.
9.  Added ABT subtest for Mouse Holder Segmentation

FireVoxel Build 296 is released.

1. Re-engineered the structure of all Dynamic Framework subtests of the ABT. Now unlimited number of subtests is allowed for all models. Any source format is allowed :
{ FVX,MIDAS,DICOM }.  Added a new subtest for Tofts (Model8) from DICOM.

2.  Continue work on the ParSVD (1-sided Jacobi SVD/parallel). Replace the NR-SVD in the VolumeTransform function, fixed uncovered defects in ParSVD.

3.  Added an ABT subtest for the Volume4D->PCA function.

4. Use ParSVD engine inside the Vol4D_PCA function.

5. Replace and Unified all the instances of the SVD usage to a  ParSVD (1SJA) function.
This excludes the underdetermined systems.

6. String consolidation to the module-specific string tables.

FireVoxel Build 295 is released.

1. FLEXR project : Implemented the Minimum Spanning Tree  for the part-based model derived from the set of Foerstner landmarks.
2.  FLEXR project :  implemented label optimization algorithm on the MST.
3. Added an interna "Current Working Directory" to UserInterfaceOptions, independent from TempDir.
4.  Corrected loading defect of COPD files (ANALYZE) from dir-lab
5. Implemented loading of the landmarks from COPD datasets.

6.  Implemented the Gaussian Radial Basis Function landmark matching (without regularization)
7. Integrated Eigen bsdSvd() procedure for substantial precision improvement.

8. Integrater GRBF into the general landmark workflow. Implemented FlowField reslice.
Tested GRBF on COPD1 dataset with 300 landmarks (Gauss RBF Sigma = 30 mm)

Exhale (Blue) over Inhale (Red)  BEFORE registration

Exhale (green) over Inhale (Red)  AFTER Registration.

Implemented Regularized variant of the GRBF deformation (large sigma = 100mm, lambda=1e-3)

AFTER (left)  vs  BEFORE (right)  same slice Z

9. Corrected DICOM loading defect due to a different internal encoding of the date and daytime inside the DCMTK data structure.

10.  Implemented Gradient Descent and Conjugate Gradient algorithms as a postprocessing for solving the system of Linear equations. Presently used after SVD so that it reduces the RMSE by x10.

11. Corrected defect of CT_BASIC concentration conversion not working in Dynamic Modelling.
12. Introduced an ABT subtest for TOFTS (Model8) on CT.

Build 294B is released.

1. Save Alignment Transform (to *.vtf) - corrected situation when FVX Temporary directory was changed.

2. Added a separate attribute "VTF_Folder" to User Options structure.

3.  Raster Paintbrush dialog:  rename "Parametric Maps" field into "Real Volumes"

2. Updated workflow for registering the Primate Atlas to the selected Monkey reference brain. Changes included:
    a) Using 0-component of the PCA (principal component) conversion of 4D volume.
    b) Using T2-layer as Anatomy for the label map.
    c) Label registration output is generated using Nearest Neighbor interpolation.
    d) Label map is clipped by the provided Atlas Brain Mask.

FireVoxel 294A is released.

1. Removed the Temporary Folder cleaning upon the FireVoxel exit.  Now User views the Temporary folder size in the User Options dialog box.  User has an option to clean Temporary folder with dedicated button.

FireVoxel 294 is released.

1.  Implemented loading of the superPK files (*.idwc) into the FireVoxel dynamic component module.
2. Implemented an initial version of the MRTM0 model (with the reference function supplied by the superPK).

Reference function loaded from superPK

MRTM0 model fitting starting from time t* (equilibration time).

3. Implemented the MRTM model (using the loaded superPK reference function)

4. "Extract Atlas ROIs":  corrected so that the original Atlas layer is not removed after the operation.

5. Defect correction: In many operations when the layer configuration is modified, so if the floating Layer Control dialog is opened it was not updated leading to the confusion.

6. Extended "Integer Range Parser" support function used in many UI scenarios (f.e. Extract Atlas Layers).

7. Implemented workflow for Affine registration of Primate Atlas to the selected Squirrel Monkey Reference image.

8. Layer control dialog : added information about the number of marked layers. This is helpful when a very large number of layers is present.

9.  When layers are removed and a single layer is left, we set its Alpha to 100%

10.  Added the "Discard Alignment" item to the Transform menu.

11. Added "Save Alignment" function to the Transform menu.

12. UserOptions dialog:  added a general option for all the operations\transform which so far had only the default Interpolation. Now user specifies such "Default Interpolation".  Works including the Transform>Alignment tools.

13. Implemented a general high performance function for converting 4D Volume into array of Principal Component using PCA (resulting in new 4D Volume of components).

FireVoxel Build 293 is released.

1. NIFTI-4D: Corrected the each frame timing calculation using nim->toffset\nim->dt information.

2. Implemented a custom processing option for DICOM Open Folder dialog box.  Rarely DICOM datasets have SeriesUID unique for each slice, so the option was introduced to parse them correctly.








3.  Defect fixed: In NIFTI file obtained from SPM (type FLOAT64) there were many entries with the value  NotANumber, so this was making Firevoxel crash.  Fixed by changing these values to 0, during the load.

FireVoxel Build 292 is released.

1.  Several correction and improvements in the Dialog "View TAC"
2.  Major (x10+) acceleration of the saving FVX files with many slices, by improving the saving embedded dicom header structure.  This is done by using new DCMTK functions DcmOutputBufferStream::.
3.  Provided more robust  IsMatchingVolume function (used mainly in ABT).  Problem was that for many 4D volumes, there are one or more dimensions (f.e. time and b-values) with repeating values in the dynamic coordinates.  This introduces randomness in the sorting order of different timepoints, so matching function was often failing without reason.  Addressed randomness by checking against all suitable dynamic coordinates.
4. Restored the ABT subtest and full functionality for the ChestWall\FullBreast segmentation. This was disabled during the upgrade of MagTrace contour tool while constructing the ground truth for the lung segmentation (ISMRM).
5. Implemented the "Display unmarked layers" checkbox inside Layer Control dialog, functionality to display the unmarked entries thus expanding possibilities of working with the Layers.
6. Modified Transform>Translate  and Transform>Rotate function to work on several Marked volumes, while unmarked volumes are stationary.
7. Layer Control dialog:  added  "Mark\Unmark All layer" button.

Build 291B is released.

1.  Corrected defects in X-correlation registration dialog
2. Provided individual menu item for the Mouse brain->Atlas registration
3. Provided new functionality to remove a range of dynamic points specified by the User.

FireVoxel Build 291 is released.

1. AutoFocus 3D: implemented a variant with "af Uniform Scale" option.
2. Implemented 1st version of the Mouse brain (automatically extracted from Multiholder) registration to the standard Atlas.
3.  Corrected binning inside the AutoFocus\MutualInformation registration.
4. Corrected run-away defect with MI_NORM\Affine.

FireVoxel Build 290 is released.

1.  Fixed error when rasterizing Vector polylines and splines:  now the NULL pen is used so the rasterized boundary is much closer to the vector one.



2. Provided complete re-work of the MagTrace Toolkit:
Added several new image snapping modes, manual modes Alt1,Alt2,Alt3.  Rasterization tools.

3. Added DCMTK functions for loading DICOM headers directly from memory buffer (avoiding the intermediate file creation).  Resulted in x10 loading speedup.

4. Provided an initial version of VIBE4D + GRASP4D hybrid merge function.

FireVoxel Build 289B is released.

1. WM Lesions batch:  corrected defect when NIFTI orientation was not properly written.
     Improved the progress indicator so the name of the currently processed file is displayed.

FireVoxel 289A is released.

WM lesions batch job:  fixed the resolution problem when saving result to .NII file.

FireVoxel Build 289 is released.

1. Kidney segmentation FAP:  reduced number of UI parameters.
Adjusted default parameters for good processing of all 6 sets (L+R).

2. Open RAW dialog box:  implemented filter option to open ALL RAW formats (*.im;*.img;*nii;*.nia;*.nii.gz;*.mgh;*.mgz;*.time)

3. New version of Kidney FAP segmentation.

4. Batch processing of FLAIR  WM lesions.

5.  Corrected defect when the resolution of NIFTI saved file turns into (1,1,1)mm

6. RoiStats3D dialog:  added the value of the bin to the info displayed on the MouseMove over the histogram.

1. Kidney segmentation: FAP
Added User constant to extend the height of the kidney bounding box, not exposed on UI.
Effective Bounding box is displayed to the User at the end of procedure to provide feedback.

2.  Completely parallelize multi-slice projections such as MIP.  Added a progress bar since
it takes longer time to display.

3.  Extended Kidney FAP segmentation to include the notion of Collecting System.

FireVoxel 288C is released.

1. Kidney segmentation: algorithm modification to remove 99%+ of medulla voxels which accidentally appear on the surface of the kidney.

2.  ROI>Morphology>Inflate\Deflate functionality:  made corrections so the Inflate-Deflate combinations are reversible with the same parameter.  Fixed side-effects in   BrainAtrophy and FLAIR Lesions functions.

FireVoxel Build 288A is released.

1 Fixed defect when in KSFAP segmentation there are overlapping voxels 
in the final Cortex vs Medulla masks

FireVoxel Build 288 is released.

1.  EdgeWave-2D : implemented a pure 2D function which is very fast, works on a single slice.  It reuses the EdgeWave-3D code.

2. New algorithm for fully automatic MouseHolder segmentation (based on MIP and EdgeWave2D)
3. Implemented automatic rotation of the individual chambers to normal orientation. Youtube video posted.
4.  Implemented UI functions: Close Current Document (All Views)
and Close All Documents.
5. Open Dicom dialog box:  Implemented function to check all Children of the selected item.  Then few undesirable items could be easily unchecked and the rest loaded. Youtube video uploaded.

FireVoxel Build 287 is released.

1. Implemented the separate volume output for the Rodent Multi-holder segmentation.

2. Implemented EdgeWave Multipass agent for Rodent Multi-holder segmentation.

3. First User version of the MultiHolder segmentation tool with dedicated dialog box
.

FireVoxel 286B is released.

1. Fixed the missing top\bottom slices issue in KSFAPv2 and KSFAPv3.

2.  Enabled KSFAPv3 on smaller cropped kidney volumes.

FireVoxel Build 286A is released.

Kidney DTI motion correction workflow:  fixed the issue when Mosaic DICOM info is missing so a dialog box pops up

Build 286 is released.

1. Implemented F9 switch between regular projection and MIP projection.
2. Implemented a new workflow KSFAPv3 (kidney segmentation) where User is not required to specify the mid-axial kidney slice and just need to make a bounding rectangle on MIP projection.

Build 285 is released.

1. Implemented function and User interface to change the DICOM Tags   Position\Orientation within the headers of loaded Volume.  This requires to view images in 3DSlicer.

2.  Implemented a new workflow for the Kidney motion correction in Mosaic-based DTI exam.
Enabled saving to DICOMs compatible with the 3D Slicer DTI framework.

3.  Optimized the Display Cache internals during the Paint Brush painting.

4.  Provided and ABT subtest for the new DTI kidney motion correction workflow.

5.  Provided a video manual for the new DTI kidney motion correction workflow.
.

Build 284 is released.

1. Provided backward compatibility Load support for FVX file format V7.
2. New UI function:  MainMenu>Volume>Crop>Crop Current Slice.
3.  Complete re-engineering of internal DICOM representation in Volumtric entities.
4. Number of image in SIEMENS mosaic is automatically determined and initiated
inside the Mosaic-to-volume dialog box.
5.  When document is saved, the names of the individual layers are modified so the Path to
the layer file is removed and only the file title is left.
6.  After performing Mosaic->to->Volume operation for DTI image, save to DICOM, reload DICOM: the volumes are correctly loaded with full diffusion info preserved.
7.  After performing Mosaic->to->Volume operation for DTI image, save to FireVoxel, reload  FireVoxel doccument,  ave to DICOM, reload DICOM: the volumes are correctly loaded with full diffusion info preserved.
8.  Extended Mosaic->Volume function to all layers, including ROIs.  So Multilayer entity is converted properly.
9. Implemented the ABT subtest Dti Mosaic registration mini-workflow
10.  Fixed the issues with saving\loading a single ROI layer to DICOM.

11. OpenDicom dialog:  corrected the preview panel so it works for the ROI images saved in DICOM.

FireVoxel Build 283E is released.


1. Fixed a glitch when  older FVX file contains and ROI layer without the orientation corresponding to Base layer.  This originated in older versions of FVX when new ROIs missed the proper orientation.  This caused the problem when cropping such multilayer volume using VROI.  Now software warns properly, allows you to proceed and the ImageOrientationPatient is automatically repaired in the problematic layer.

2.  MainMenu>Vector>Enclose Connected components menu command:
     a) If more than 1 component was detected, message is displayed informing about the # of  CCs.
     b) Displayed Slice is changed to the center of the largest created VROI.
     c) Corrected defect: when connected component is withing a single slice, we change the slice               so that the resulting VROIs becomes visible immediately.

3. Fixed defect in Layer Control dialog:  disallowed removing the layers when it results in no layers left.
   
     

FireVoxel 283D is released.

1.  In Layer Control dialog when doubleclick on the Layer name and edit control shows up:

      a) Enabled immediate focus - so User can start type immediately.

      b) The whole current string is initially selected.

      c) Ctrl+A selection is enabled.

2.  User Interface Options dialog:  introduced new option "Load Dynamic Modelling setting from  FVX". 
      x - loads the setting for all models saved in the FVX file
      o - keeps all current settings, disregards the one from FVX file.

       (This is save as FireVoxel config file between the sessions).

3.  When Vol>Crop>All Layers is activated, the new document is created with the name of Source document +  "_crop".  Before it was the name of current Active layer in the source document.

4.  Vector ROI Properties dialog now remembers if   MM\VOX units were used in the previous instance (within the same FireVoxel session).

5.  Vector ROI Properties dialog box:  added a button and function "Scale Dimensions" by the specified scale.  Resulting Rectangle is cropped by the volume dimensions.

6.  In generic "Specify double value" dialog corrected so that the focus is immediately located inside the data field.

7.  In generic "Specify integer value" dialog corrected so that the focus is immediately located inside the data field.

FireVoxel 283C is released.

1.  Updated the ConvertMosaicTo3DVolume function and the corresponding UI.
2.  Tested the workflow for motion correction of kidney DTI  2D+t.

FireVoxel Build 283B is released.

1. Removed the FilmView state when working with the single slice volumes.  It is always in Single Slice mode now.

FireVoxel  283A is released.

1.  Added the DisplayTransform record to the ZOOMCACHE structure.  This fixes some defects when switching between Film and Slice view and pulling the Zoom from cache.

2.  When new layer is added\created, immediately copy the Display Matrix of the current working layer.  This way the drawing can be done correctly on the newly created layer.

FireVoxel 283 is released.

Expanded Model0 to exactly match the hyperparameters and statistics parameters of the Roi Stats3D dialog box.

FireVoxel Build 282 is released.

Dynamic modelling,  models  #{43,46,47}

1.  Added a hypermarameter:  "Minimal Arterial Delay"
2. When iterating through the Arterial Delay values using the Arterial Delay Delta ensured that
the Max Arterial Delay value is always evaluated for any Delta.

Build 280 is released.

1.  Implemented "Arterial Delay" parameter for Model #43 2CXM.  Fitting residuals can be dropped by half on the test images.







2.  Changed default processing when loading DICOM images with IPP\IOP tags missing.  This allowed to load some volumes as 3D as desired.

3. Implemented new dynamic model "2CFM {vp,ve,Fp,PS} - Gridded Simplex Local Optimization".  This implementation contains the Arterial Delay output parameter.

4.  Fixed defect : when new ROI layer is created from Layer Control dialog box, the ROI slice dicom image position and orientation were not properly initialized.  This resulted in defect when loading the ROI volumes saved as 3D DICOM.

FireVoxel Build 279 is released.

1.  Combine and synchronized the Volume viewing pipeline (3D->Screen  affine transform) with the transform used to convert paintbrush screen coordinates into the voxel coordinates.  This fixed the defects with drawing ROI on various projections.