Build 402 is released.

 1. Corrected defect when "Remove duplicate SOP Instance UID" message pops up even when no duplicates are present.

2. Provided a more explanatory message in the event of duplicates present

3. Corrected the progress bar when loading large Folders of DICOM files.

4.  Implemented UI functionality to change the TE value of a group of DICOM files from the OpenDICOM dialog box.

5. Corrected UI bug in a string display when specifying the values in Volume>Set DICOM Tags.

6. Fixed the crash defect when setting the TE dicom tag in the Ti=1 volume.

 New DICOM check and message in the recent Builds:

Each DICOM file is supposed to have an unique SOP Instance UID as explained here:

SOP Instance UID - OTpedia, Information for Medical Imaging (otechimg.com)

However, this is sometimes not a case.

Prior to Build 399 this check was always made and the duplicate SOP Instance UID files were excluded from loading. 

Then in Build 399 a new check was added and if the files with the identical SOP Instance UID are detected the dialog box comes up that offers to remove the duplicate files from loading (but does not delete them physically).

Build 401 is released.

 1. Development moved to new version MS VC++ 2022.

2. FireVoxel recompiled on VC++ 2022.  Modules {FvxDcm, FvxMem} corrected warnings Level4 and various issues found by a new compiler.

3. Recompiled DCMTK 3.6.3 (2018) using the new compiler.

4. Updated the MSVC redistribution files in FVX.

 List of FireVoxel publications May 2019-May 2020.

A 3D printed patient-specific dual compartment breast phantom for validating MRI acquisition and analysis techniques.

Wake N, Ianniello C, Brown R, Walczyk J, Moy L, Collins C, Rusinek H.

Trans Additive Manufacturing Meets Medicine 1(1): 11-12, 2019.

doi:10.18416/AMMM.2019.1909S12T01

 

Accuracy of magnetic resonance imaging texture analysis in differentiating low-grade from high-grade gliomas: systematic review and meta-analysis.

Wang Q, Lei D, Yuan Y, Zhao H.

BMJ Open 9(9):e027144 (epub. in press), 2019.

doi:10.1136/bmjopen-2018-027144

 

Added value of histogram analysis of apparent diffusion coefficient maps for differentiating triple-negative breast cancer from other subtypes of breast cancer on standard MRI.

Liu H-L, Zong M, Wei H, Wang C, Lou J-J, Wang S-Q, Zou Q-G, Jiang Y-N.

Cancer Manag Res 11: 8239–8247, 2019.

doi:10.2147/CMAR.S210583    PMCID: PMC6735623   PMID: 31564982

 

A new method for cartilage evaluation in femoroacetabular impingement using quantitative T2 Magnetic Resonance Imaging: preliminary validation against arthroscopic findings.

Ben-Eliezer N, Raya JG, Babb JS, Youm T, Sodickson DK, Lattanzi R.

Cartilage (epub, in press), 2019.

doi.org/10.1177/1947603519870852

 

A novel MRI tool for evaluating cortical bone thickness of the proximal femur.

Ramme AJ, Vira S, Hotca A, Miller R, Welbeck A, Honig S, Egol KA, Rajapakse CS, Chang G.

Bull Hosp Joint Disease 77(2): 115-121, 2019.

 

Apparent diffusion coefficient-based histogram analysis differentiates histological subtypes of periampullary adenocarcinoma.

Lu J-Y, Yu H, Zou X-L, Li Z, Hu X-M, Shen Y-Q, Hu D-Y.

World J Gastroenterol 25(40): 6116–6128, 2019.

doi:10.3748/wjg.v25.i40.6116    PMCID: PMC6824280   PMID: 31686767

 

Application of apparent diffusion coefficient values derived from diffusion-weighted imaging for assessing different sized metastatic lymph nodes in cervical cancers.

Aining Z, Song J, Ma Z, Chen T.

Acta Radiol (epub, in press), 2019.

doi:10.1177/0284185119879686

 

Application of FireVoxel software to measure the volume of intracranial hematoma.

Guangwei F, Shangfeng G, Chengkun Y, Xiaofeng C, Shun L, Jun L.

J Clinical Neurosurgery 16(1): 33-37, 2019.

 

Application value of MRI apparent diffusion coefficient (ADC) before and after radical mastectomy for patients with breast cancer.

Chen L, Liu L, Zhao F, Li X, Li B, Lu S.

Int J Clin Exp Med 12(9):11538-11546, 2019.

 

A study of the correlation of perfusion parameters in high-resolution GRASP MRI with microvascular density in lung cancer.

Chen L, Zeng X, Wu Y, Yan X, Huang X, Chen H, Zhang J, Wang J, Feng L.

J Magn Reson Imaging 49(4): 1186-1194, 2019.

doi.org/10.1002/jmri.26340

 

Combining tumor size and diffusion-weighted imaging to diagnose normal-sized metastatic pelvic lymph nodes in cervical cancers.

Song J, Hu Q, Huang J, Ma Z, Chen T.

Acta Radiol 60(3): 388-395, 2019.

doi:10.1177/0284185118780903.

 

Different relationship between systolic blood pressure in subjects with and without hypertension.

Glodzik L, Rusinek H, Tsui W, Pirraglia E, Kim HJ, Deshpande A, Li Y, Storey P, Randall C, Chen J, Osorio RS, Butler T, Tanzi E, McQuillan M, Harvey P, Williams SK, Ogedegbe OG, Babb JS, de Leon M.

Hypertension 73(1):197-205, 2019.

 

Differentiation between orbital malignant and benign tumors using intravoxel incoherent motion diffusion-weighted imaging: correlation with dynamic contrast-enhanced magnetic resonance imaging.

Xu X-Q, MD, Hu H, Su G-Y, Liu H, Wu F-Y, Shi H-B.

Medicine (Baltimore) 98(12): e14897, 2019.

doi: 10.1097/MD.0000000000014897   PMCID: PMC6709032   PMID: 30896639

 

Diffusion and perfusion MRI quantification in ileal Crohn’s disease.

Hectors SJ, Gordic S, Semaan S, Bane O, Hirten R, Jia X, Colombel J-F, Taouli B.

European Radiology 29, 993–1002, 2019.

 

Diffusion MRI biomarkers of white matter microstructure vary nonmonotonically with increasing cerebral amyloid deposition.

Dong JW, Jelescu IO, Ades-Aron B, Novikov DS, Friedman K, Babb JS, Osorio RS, Galvin JE, Shepherd TM, Fieremans E.

Neurobiology of Aging 89: 118-128, 2020.

 

Effect of laterality, gender, age and body mass index on the fat fraction of salivary glands in healthy volunteers: assessed using iterative decomposition of water and fat with echo asymmetry and least-squares estimation method.

Su G-Y, Wang C-B, Hu H, Liu J, Ding H-Y, Xu X-Q, Wu F-Y.

British Institute of Radiology 2019

doi.org/10.1259/dmfr.20180263

 

Exploratory study of apparent diffusion coefficient histogram metrics in assessing pancreatic malignancy.

Taffel MT, Luk L, Ream JM, Rosenkrantz AB.

Canadian Assoc Radiolog J 70(4), 416-423, 2019.          

doi.org/10.1016/j.carj.2019.07.001

 

Histogram analysis of diffusion kurtosis imaging in the differentiation of malignant from benign breast lesions.

Liu W, Wei C, Bai J, Gao X, Zhou L.

Eur J Radiol 117:156-163, 2019.

 

Histogram analysis with computed tomography angiography for discriminating soft tissue sarcoma from benign soft tissue tumor.

Wu G, MD, Xie R, Li Y, Hou B, Morelli JN, Li X.

Medicine (Baltimore) 99(2): e18742, 2020.

doi:10.1097/MD.0000000000018742    PMCID: PMC6959892     PMID: 31914093

 

Histological grades of rectal cancer: whole-volume histogram analysis of apparent diffusion coefficient based on reduced field-of-view diffusion-weighted imaging.

Peng Y, Tang H, Meng X, Shen Y, Hu D, Kamel Y, Li Z.

Quant Imaging Med Surg 10(1): 243–256, 2020.  

doi:10.21037/qims.2019.11.17

PMCID: PMC6960428   PMID: 31956546

 

IgG4-related sclerosing cholangitis: a clinical and imaging review.

Madhusudhan KS, Das P, Gunjan D, Srivastava DN, Garg PK.

American Journal of Roentgenology 213(6): 1-11, 2019.

doi:10.2214/AJR.19.21519

 

Influence of bone lesion location on femoral bone strength assessed by MRI-based finite-element modeling.

Rajapakse CS, Gupta N, Evans M, et al.

Bone 122: 209–217, 2019.

doi.org/10.1016/j.bone.2019.03.005    PMID: 30851438   PMCID: PMC6486650

 

MRI as a diagnostic biomarker for differentiating primary central nervous system lymphoma from glioblastoma: a systematic review and meta-analysis.

Suh CH, Kim HS, Jung SC, Park JE, Choi CG, Kim SJ.

J Magn Reson Imaging 50(2), 2019.

doi.org/10.1002/jmri.26602

 

Perfusion parameters of intravoxel incoherent motion based on tumor edge region of interest in cervical cancer: evaluation of differentiation and correlation with dynamic contrast-enhanced MRI.

Wang H, Zhu L, Li G et al.

Acta Radiologica (epub. in press) 2019.

doi.org/10.1177/0284185119890086

 

Precisely-measured hydration status correlates with hippocampal volume in healthy older adults.

Butler T, Deshpande A, Harvey P, Li Y, Rusinek H, Pirraglia E, Osorio R, Glodzik L, de Leon MJ, Madelin G, Yu WW, Gallagher D, Masaeka J.

American Journal of Geriatric Psychiatry 27(6), 653-654, 2019.

 

Prediction of platinum-based chemotherapy response in advanced high-grade serous ovarian cancer: adc histogram analysis of primary tumors.

Lu J, Li HM, Cai SQ, et al.

Academic Radiology (epub. in press) 2020.

doi.org/10.1016/j.acra.2020.01.024

 

Preliminary study of using diffusion kurtosis imaging for characterizing parotid gland tumors.

Qian W, Xu XQ, Zhu LN, Ma G, Su GY, Bu SS, Wu FY.

Acta Radiol 60(7): 887-894, 2019.

doi:10.1177/0284185118803784.

 

Prospective comparison between DCE-MRI and 99mTc-DTPA-based SPECT for determination of allograft renal function.

Wan-Li Z, Jun T, Yu-Dong Z, et al.

J Magn Reson Imaging 49(1): 2019

 

Prostate cancer heterogeneity: texture analysis score based on multiple MRI sequences for detection, stratification and selection of lesions at time of biopsy.

Orczyk C, Villers A, Rusinek H, Lepennec V, Bazille C, Giganti F, Mikheev A, Bernaudin M, Emberton Mark, Fohlen A, Valable S.

Brit J Urol International 124(1), 76-86, 2019.

 

Quantitative assessment of diffusion kurtosis imaging depicting deep myometrial invasion: a comparative analysis with diffusion-weighted imaging.

Song JC, Lu SS, Zhang J, Liu XS, Luo CY, Chen T.

Diagn Interv Radiol 26(2): 74–81, 2020.

doi: 10.5152/dir.2019.18366    PMCID: PMC7051262    PMID: 32071025

 

Quantitative multivoxel proton MR spectroscopy for the identification of white matter abnormalities in mild traumatic brain injury: Comparison between regional and global analysis.

Davitz MS, Gonen O, Tal A, Babb JS, Lui YW, Kirov II.

J Magn Reson Imaging 50(5):1424–1432, 2019.    

doi.org/10.1002/jmri.26718

 

Radiomics based on multimodal MRI for the differential diagnosis of benign and malignant breast lesions.

Zhang Q, Peng Y, Liu W, et al.

J Magn Reson Imaging (epub, in press) 2020.

doi.org/10.1002/jmri.27098

 

Rectal cancer invasiveness: whole-lesion diffusion-weighted imaging (DWI) histogram analysis by comparison of reduced field-of-view and conventional DWI techniques.

Peng Y, Tang H, Hu X et al.

Sci Rep 9, 18760, 2019.

 

Simultaneous evaluation of lung anatomy and ventilation using 4D respiratory motion resolved ultrashort echo time sparse MRI.

Feng L, Delacoste J, Smith D, et al.

J Magn Reson Imaging 49(2):411–422, 2019.

doi:10.1002/jmri.26245

 

Small field of view diffusion tensor imaging (DTI) of the kidneys in people with type 2 diabetes and healthy controls.

Lim R, Williams J, Perchyonok Churilov Y, McKenna N, Torkamani N, Staeb D, Mikheev A, Rusinek H,Ekinci E.

Kidney International Reports 4(7): S286–S287, 2019.

DOI: https://doi.org/10.1016/j.ekir.2019.05.710

 

Splenic T1rho as a noninvasive biomarker for portal hypertension.

Hectors SJ, Bane O, Stocker D, et al.

J Magn Reson Imaging  (epub., in press) 2020. 

doi.org/10.1002/jmri.27087

 

The evaluation of prostate lesions with IVIM DWI and MR perfusion parameters at 3T MRI.

Beyhan M, Sade R, Koc E, Adanur S, Kantarci M.

La Radiologia Medica 124: 87–93, 2019.

 

The histogram analysis of apparent diffusion coefficient in differential diagnosis of parotid tumor.

Chen P, Dong B, Zhang C, Tao X, Wang P, Zhu L.

British Institute of Radiology (epub, in press) 2019.

doi.org/10.1259/dmfr.20190420

 

Value of diffusion-weighted and dynamic contrast-enhanced MR in predicting parametrial invasion in cervical stromal ring focally disrupted stage IB–IIA cervical cancers.

Song J, Hu Q, Ma Z, Zhang J, Chen T.

Abdominal Radiology 44: 3166–3174, 2019.

 

Volumetric apparent diffusion coefficient histogram analysis in differentiating intrahepatic mass-forming cholangiocarcinoma from hepatocellular carcinoma.

Zou X, Luo Y, Li Z et al.

J Magn Reson Imaging 49(4): 975-983, 2019.

 

Whole-lesion histogram analysis metrics of the apparent diffusion coefficient: a correlation study with histological grade of hepatocellular carcinoma.

Xu YS, Liu HF, Xi DL, et al.

Abdominal Radiology 44(9): 3089–3098, 2019.

 

Whole liver apparent diffusion coefficient histogram analysis for the diagnosis and staging of liver fibrosis.

Zheng Y,  Xu Y-S, Liu Z, Liu HF, Zhai YN, XR, Lei JQ.

J Magn Reson Imaging (epub., in press) 2019.

PMID: 31729811   doi.org/10.1002/jmri.26987

 

Whole-tumor histogram analysis of non-Gaussian distribution DWI parameters to differentiation of pancreatic neuroendocrine tumors from pancreatic ductal adenocarcinomas.

Li J, Liang L, Yu H, et al.

Magnetic Resonance Imaging 55: 52-59, 2019.

doi.org/10.1016/j.mri.2018.09.017

 

Whole-tumor quantitative apparent diffusion coefficient histogram and texture analysis to differentiation of minimal fat angiomyolipoma from clear cell renal cell carcinoma.

Li H, Li A, Zhu H, et al.

Acad Radiol 26(5): 632–639, 2019.

doi.org/10.1016/j.acra.2018.06.015

 

book:

Finite element method and medical imaging techniques in bone biomechanics.

Rabeb Ben Kahla, Abdelwahed Barkaoui, Tarek Merzouki. Wiley Online Library, Abdelkhalak El Hami editor, 2020.  

 List of FireVoxel publications May 2020 - May 2021

1) DOI:10.3760/CMA.J.CN112149-20190522-00439

Corpus ID: 219790802

Whole-lesion histogram analysis of apparent diffusion coefficient for the prediction of pathological complete response to neoadjuvant chemotherapy in different subtypes of breast cancer

• X. Wang, L. Zhu, +7 authors Yanni Jiang

• Published 2020  Medicine Chinese journal of radiology

2) DOI:10.21037/GS.2020.04.01

Corpus ID: 216342072

Preliminary study on identification of estrogen receptor-positive breast cancer subtypes based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) texture analysis.

• H. Wang, Y. Hu, +3 authors Weijia Wan

• Published 2020 Medicine Gland surgery

3) Corpus ID: 230710206

Correlation between IVIM histogram parameters and 18F-FDG PET metrics in hepatic tumors: a retrospective study

• Mingxiang Sun, Feng Gang, +1 author X. Gao

• Published 2020   Medicine   The Journal of Nuclear Medicine

4) Corpus ID: 229930568

[Relationship of ADC histogram parameters with pathological grade and lymph node metastasis of prostate cancer].

• Mei-Lin Gong, L. Li, +2 authors Ming Wen

• Published 2020 Medicine  Zhonghua nan ke xue = National journal of andrology

5) DOI:10.1080/02688697.2020.1856783

Corpus ID: 229172325

The value of texture analysis in peritumoral edema of differentiating diagnosis between glioblastoma and primary brain lymphoma.

• Zhuang Sha, Yunnong Song, +5 authors R. Yu

• Published 2020 Medicine   British journal of neurosurgery

6) DOI:10.1016/j.acra.2021.02.004

Corpus ID: 232143903

Preliminary Study on Predicting Pathological Staging and Immunohistochemical markers of Rectal Cancer Based on ADC Histogram Analysis.

• K. Zhang, Y. Zheng, +1 author J. Lei

• Published 2021 Medicine  Academic radiology

7)    PET imaging of net availability in humans using [11C]MRB: Age, gender and ethnicity effects

Neuroimaging / Normal brain aging

Yu‐Shin Ding Jiacheng Wang Jingyun Chen James Babb Henry Rusinek 

First published: 07 December 2020 https://doi.org/10.1002/alz.041956

8)    Neuroimaging of amyloid pathology in a non‐human primate model of sporadic CAA

Neuroimaging / animal imaging

Thomas S Genovese Dina Ramadane Charles Kingsley Pramod N Nehete Bharti P Nehete Akash G Patel Henry Rusinek Lawrence E Williams Youssef Zaim‐Wadghiri 

First published: 07 December 2020

https://doi.org/10.1002/alz.045327

9)   Study of ALS and RAGE Using [11C]PBR28: Mechanisms and Therapeutic Opportunities

Jiacheng Wang, Michael MacLean, Zakia Youss, Orin Mishkit, Dillon Clancy, Raul Jackson, Judyta Juranek, Giuseppe Carlucci, Ann Marie Schmidt and Yu-Shin Ding

Journal of Nuclear Medicine May 2020, 61 (supplement 1) 212;

10)  Age, Gender, and Ethnicity Effects on NET Availability in Humans using [11C]MRB

Jiacheng Wang, Artem Mikheev, Jingyun Chen, Henry Rusinek and Yu-Shin Ding

Journal of Nuclear Medicine May 2020, 61 (supplement 1) 400;

11)  Correlation between IVIM histogram parameters and 18F-FDG PET metrics in hepatic tumors: a retrospective study

Mingxiang Sun, Gang Feng, Liling Peng and Xin Gao

Journal of Nuclear Medicine May 2020, 61 (supplement 1) 

12)  Retrospective MRI non-uniformity correction: quantitative assessment of two methods

A Mikheev, L Bokacheva, H Yang, J Sobel… - researchgate.net

13)  Assessment of metastatic lymph nodes in head and neck squamous cell carcinomas using simultaneous 18F-FDG-PET and MRI

• Jenny Chen, Mari Hagiwara, Babak Givi, Brian Schmidt, Cheng Liu, Qi Chen, Jean Logan, Artem Mikheev, Henry Rusinek & Sungheon Gene Kim 

14)   Assessment of Renal Cell Carcinoma by Texture Analysis in Clinical Practice: A Six-Site, Six-Platform Analysis of Reliability

Ankur M. Doshi, MD1, Angela Tong, MD1, Matthew S. Davenport, MD2, Ahmed Khalaf, MD3 

Citation: American Journal of Roentgenology: -. 10.2214/AJR.21.25456

Read More: https://www.ajronline.org/doi/abs/10.2214/AJR.21.25456

15)  Published: 06 November 2020

The ratio of abdominal depth to body mass index is a preoperative predictor of postoperative complications after laparoscopic pancreaticoduodenectomy: a retrospective propensity score matched analysis

• Hebin Wang, Jikuan Jin, Feng Zhu, Feng Peng, Min Wang & Renyi Qin 

Surgical Endoscopy (2020)Cite this article

16)  J Magn Reson Imaging   . 2020 Jun;51(6):1745-1754.    doi: 10.1002/jmri.26987.

Whole-Liver Apparent Diffusion Coefficient Histogram Analysis for the Diagnosis and Staging of Liver Fibrosis

You Zheng 1 2, Yong-Sheng Xu 1, Zhao Liu 1, Hai-Feng Liu 3, Ya-Nan Zhai 1, Xiao-Rong Mao 4

17)  Magnetic Resonance Imaging

Volume 76, February 2021, Pages 79-86

Feasibility of T1 mapping with histogram analysis for the diagnosis and staging of liver fibrosis: Preclinical results

Author links open overlay panelQingWanga1HaiFengLiua1ZuHuiZhuaYeShengbYaNanDuaYuFengLiaJianHongLiucJiLeiZhangdWeiXinga

18)  Preliminary Findings Associate Hippocampal 1H-MR Spectroscopic Metabolite Concentrations with Psychotic and Manic Symptoms in Patients with Schizophrenia

D. Malaspina, E. Lotan, H. Rusinek, S.A. Perez, J. Walsh-Messinger, T.M. Kranz and O. Gonen

American Journal of Neuroradiology January 2021, 42 (1) 88-93; DOI: https://doi.org/10.3174/ajnr.A6879

19)  Ann Transl Med. 2021 Jan; 9(1): 41.     doi: 10.21037/atm-20-1411

Predictive factors of postoperative pancreatic fistula after laparoscopic pancreatoduodenectomy

Jikuan Jin,1,# Guangbing Xiong,1,# Jiali Li,2,# Xingjun Guo,1 Min Wang,1 Zhen Li,2 Feng Zhu, 1 and Renyi Qin 1

20)  Feasibility study for evaluating lumbar intervertebral disc degeneration using histogram analysis of T2* values

• Xiaoqing Liang, Ruyi Xie, Bowen Hou, Yitong Li, Yan Xiong, Cuilin Yin, Weiyin Vivian Liu, John Morelli & Xiaoming Li 

European Spine Journal volume 29, pages2600–2608(2020)

21) European Journal of Radiology

Volume 133, December 2020, 109351

Response assessment of hepatocellular carcinoma treated with yttrium-90 radioembolization: inter-reader variability, comparison with 3D quantitative approach, and role in the prediction of clinical outcomes

Michael .KingAngelaTongBariDaneChenchanHuangChenyangZhanKrishnaShanbhogue

22)  Visceral adipose tissue in patients with COVID-19: risk stratification for severity

Hersh Chandarana, Bari Dane, Artem Mikheev, Myles T. Taffel, Yang Feng & Henry Rusinek 

Abdominal Radiology volume 46, pages818–825(2021)Cite this article

23)  Published: 04 August 2020

One-stop assessment of renal function and renal artery in hypertensive patients with suspected renal dysfunction: non-enhanced MRI using spatial labeling with multiple inversion pulses

Ping Liang, Chuou Xu, Pratik Tripathi, Jiali Li, Anqin Li, Daoyu Hu, Ihab Kamel & Zhen Li 

European Radiology volume 31, pages94–103(2021)

24)  BioMed Research International

Volume 2020 |Article ID 9549361 | https://doi.org/10.1155/2020/9549361

A Comparative Study of 2 Different Segmentation Methods of ADC Histogram for Differentiation Genetic Subtypes in Lower-Grade Diffuse Gliomas

Dan Liu,1 Shuai-Xiang Gao,2 Hong-Fan Liao,3 Jing-Mei Xu,3 and Ming Wen 3

25)  Academic Radiology

Available online 27 October 2020

Bilateral Distance Partition of Periventricular and Deep White Matter Hyperintensities: Performance of the Method in the Aging Brain

Author links open overlay panelJingyunChenPhDabArtem V.MikheevPhDbHanYuMAacMatthew D.GruendHenryRusinekPhDbYulinGeMDbAlzheimer's Disease Neuroimaging Initiative

26)  Cancer Manag Res. 2020; 12: 6019–6031.

Published online 2020 Jul 20. doi: 10.2147/CMAR.S262973

PMCID: PMC7381091

PMID: 32765101

Evaluation of Multiple Prognostic Factors of Hepatocellular Carcinoma with Intra-Voxel Incoherent Motions Imaging by Extracting the Histogram Metrics

Gaofeng Shi,#1 Xue Han,#1 Qi Wang,1 Yan Ding,1 Hui Liu,1 Yunfei Zhang,2 and Yongming Dai2

27)  Canadian Association of Radiologists Journal

Histogram Analysis of ADC Maps for Differentiating Brain Metastases From Different Histological Types of Lung Cancers

Mustafa Bozdağ, MD, Ali Er, MD, Akın Çinkooğlu, MDFirst Published June 30, 2020 Research Article Find in PubMed

https://doi.org/10.1177/0846537120933837

28)  JMRI

Radiomics Based on Multimodal MRI for the Differential Diagnosis of Benign and Malignant Breast Lesions

Qian Zhang MD  Yunsong Peng PhD  Wei Liu MD  Jiayuan Bai MD  Jian Zheng PhD  Xiaodong Yang PhD  Lijuan Zhou MD

First published: 14 February 2020 https://doi.org/10.1002/jmri.27098Citations: 3

29)  Cancer Medicine

Prediction of the World Health Organization Grade of rectal neuroendocrine tumors based on CT histogram analysis

Ping Liang  Chuou Xu  Fangqin Tan  Shichao Li  Mingzhen Chen  Daoyu Hu  Ihab Kamel  Yaqi Duan 

First published: 01 December 2020 https://doi.org/10.1002/cam4.3628

30)  Oxford University Press

Global decrease in brain sodium concentration after mild traumatic brain injury 

Teresa Gerhalter, Anna M Chen, Seena Dehkharghani, Rosemary Peralta, Fatemeh Adlparvar, James S Babb, Tamara Bushnik, Jonathan M Silver, Brian S Im, Stephen P Wall ... Show moreAuthor Notes

Brain Communications, fcab051, https://doi.org/10.1093/braincomms/fcab051

31)  Published: 23 April 2020

Added value of susceptibility-weighted imaging to diffusion-weighted imaging in the characterization of parotid gland tumors

Jia-Suo Jiang, Liu-Ning Zhu, Wei Chen, Lu Chen, Guo-Yi Su, Xiao-Quan Xu & Fei-Yun Wu 

European Archives of Oto-Rhino-Laryngology volume 277, pages2839–2846(2020)Cite this article

32)  Nature

Published: 10 November 2020

Histogram analysis of T2 mapping for detecting early involvement of extraocular muscles in patients with thyroid-associated ophthalmopathy

Ping Liu, Lang Chen, Qiu-xia Wang, Ban Luo, Huan-huan Su, Gang Yuan, Gui-hua Jiang & Jing Zhang 

Scientific Reports volume 10, Article number: 19445 (2020) Cite this article

33)  Clinical Radiology

Available online 26 February 2021

Clinical Radiology

Differences in tumour heterogeneity based on dynamic contrast-enhanced MRI between tumour and peritumoural stroma for predicting Ki-67 status of invasive ductal carcinoma

X.HeaJ.ZhouaS.YeaQ.ChengaH.MiaoaN.XuaJ.LiaZ.PanbJ.ChengcM.Wanga

34)  Medicine (Baltimore). 2020 Jan; 99(2): e18742.

Published online 2020 Jan 10. doi: 10.1097/MD.0000000000018742

PMCID: PMC6959892

PMID: 31914093

Histogram analysis with computed tomography angiography for discriminating soft tissue sarcoma from benign soft tissue tumor

Gang Wu, MD,a Ruyi Xie, MD,a,∗ Yitong Li, MD,a Bowen Hou, MD,a John N. Morelli, MD,b and Xiaoming Li, PhDa

35)  Diagnostic and Interventional Imaging

Available online 5 January 2021

Diagnostic and Interventional Imaging

Neuroradiology

Texture analysis of apparent diffusion coefficient (ADC) map for glioma grading: Analysis of whole tumoral and peri-tumoral tissue

Radwa K.SolimanaAbdelhakeem A.EssabAhmed A.S.ElhakeemcSara A.GamalaMohamed M.A.Zaitound

https://doi.org/10.1016/j.diii.2020.12.001

36)  European Journal of Radiology

Volume 127, June 2020, 109028

Reduced Field-of-View Diffusion-Weighted Imaging in Histological Characterization of Rectal Cancer: Impact of Different Region-of-Interest Positioning Protocols on Apparent Diffusion Coefficient Measurements

YangPengaChuouXuaXuemeiHuaYaqiShenaDaoyuHuaIhabKamelbZhenLia

https://doi.org/10.1016/j.ejrad.2020.109028

37)  Published: 21 October 2020

CT and MRI of pancreatic tumors: an update in the era of radiomics

Marion Bartoli, Maxime Barat, Anthony Dohan, Sébastien Gaujoux, Romain Coriat, Christine Hoeffel, Christophe Cassinotto, Guillaume Chassagnon & Philippe Soyer 

Japanese Journal of Radiology volume 38, pages1111–1124(2020)

38)  Neurobiology of Aging

Volume 89, May 2020, Pages 118-128

Diffusion MRI biomarkers of white matter microstructure vary nonmonotonically with increasing cerebral amyloid deposition

Jian W.Dongab1Ileana O.Jelescuac1BenjaminAdes-AronaDmitry S.NovikovaKentFriedmanaJames S.BabbaRicardo S.OsoriodeJames E.GalvinfTimothy M.ShepherdaElsFieremansa

https://doi.org/10.1016/j.neurobiolaging.2020.01.009

39)  Front. Immunol., 15 April 2021 | https://doi.org/10.3389/fimmu.2021.670646

PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway

Fanqi Kong1†, Kaiqiang Sun1†, Jian Zhu1†, Fudong Li1†, Feng Lin1, Xiaofei Sun1, Xi Luo1, Changzhen Ren3, Lantao Lu1, ShuJie Zhao2, Jingchuan Sun1*, Yuan Wang1* and Jiangang Shi1*

40)  Korean J Radiol. 2021 Feb; 22(2): 243–252.

Published online 2020 Sep 10. doi: 10.3348/kjr.2020.0290

PMCID: PMC7817638

PMID: 32932565

Intravoxel Incoherent Motion Magnetic Resonance Imaging for Assessing Parotid Gland Tumors: Correlation and Comparison with Arterial Spin Labeling Imaging

Gao Ma, MS,1,* Xiao-Quan Xu, PhD,1,* Liu-Ning Zhu, MD, PhD,2 Jia-Suo Jiang, MS,1 Guo-Yi Su, PhD,1 Hao Hu, PhD,1 Shou-Shan Bu, MD, PhD,2 and Fei-Yun Wu, MD, PhDcorresponding author1

41)  Dentomaxillofacial Radiology Vol. 49, No. 5

DMFR

The histogram analysis of apparent diffusion coefficient in differential diagnosis of parotid tumor

Peiqian Chen, Bing Dong, Chunye Zhang, Xiaofeng Tao, Pingzhong Wang and Ling Zhu

Published Online:9 Mar 2020https://doi.org/10.1259/dmfr.20190420

42)  Quant Imaging Med Surg. 2020 Jan; 10(1): 243–256.

doi: 10.21037/qims.2019.11.17

PMCID: PMC6960428

PMID: 31956546

Histological grades of rectal cancer: whole-volume histogram analysis of apparent diffusion coefficient based on reduced field-of-view diffusion-weighted imaging

Yang Peng,1 Hao Tang,1 Xiaoyan Meng,1 Yaqi Shen,1 Daoyu Hu,1 Ihab Kamel,2 and Zhen Licorresponding author1

43)  BMC Medical Imaging (2020) 20:50 https://doi.org/10.1186/s12880-020-00450-x

Grading of Glioma: combined diagnostic value of amide proton transfer weighted,arterial spin labeling and diffusion

weighted magnetic resonance imaging

Xiao-wei Kang1,2†, Yi-bin Xi1,2†, Ting-ting Liu2,3, Ning Wang2,4, Yuan-qiang Zhu2, Xing-rui Wang2,5 and Fan Guo2,6

44) Front. Med., 03 July 2020 | https://doi.org/10.3389/fmed.2020.00309

Estimation of Renal Function Using Unenhanced Computed Tomography in Upper Urinary Tract Stones Patients

Jiali Li1†, Yang Xun2†, Cong Li2, Yunfeng Han3, Yaqi Shen1, Xuemei Hu1, Daoyu Hu1, Zheng Liu2*, Shaogang Wang2* and Zhen Li1*

45)  Anatomical Skull-Stripping Template and Improved Boundary-Oriented Quantitative Segmentation Evaluation Metrics

Authors: Wang, Shiqing; Shi, Yonghong; Zhuang, Han; Qin, Chunli; Li, Wensheng

Source: Journal of Medical Imaging and Health Informatics, Volume 10, Number 3, March 2020, pp. 693-704(12)

Publisher: American Scientific Publishers

DOI: https://doi.org/10.1166/jmihi.2020.2920

46)  MDPI Life

Primary Gastro-Intestinal Lymphoma and Gastro-Intestinal Adenocarcinoma: An Initial Study of CT Texture Analysis as Quantitative Biomarkers for Differentiation

by Lin Ding 1OrcID,Sisi Wu 1,Yaqi Shen 1,Xuemei Hu 1,Daoyu Hu 1,Ihab Kamel 2 andZhen Li 1,*OrcID

Received: 2 February 2021 / Revised: 17 March 2021 / Accepted: 19 March 2021 / Published: 23 March 2021

Life 2021, 11(3), 264; https://doi.org/10.3390/life11030264

47)  Frontiers in Endocrinology

Published: 25 February 2021

doi: 10.3389/fendo.2021.614536

Baseline Volumetric T2 Relaxation Time Histogram Analysis: Can It Be Used to Predict the Response toIntravenous Methylprednisolone

Therapy in Patients With ThyroidAssociated Ophthalmopathy?

Ping Liu1,2†, Ban Luo3†, Lang Chen1, Qiu-Xia Wang1, Gang Yuan4, Gui-hua Jiang2

and Jing Zhang1*

48)  ABDOMINAL RADIOLOGY

Published: 18 May 2020

Combined dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging to predict neoadjuvant chemotherapy effect in FIGO stage IB2–IIA2 cervical cancers

Aining Zhang, Jiacheng Song, Zhanlong Ma & Ting Chen 

La radiologia medica volume 125, pages1233–1242(2020)

49)  JMRI

Splenic T1ρ as a noninvasive biomarker for portal hypertension

Stefanie J. Hectors PhD  Octavia Bane PhD  Daniel Stocker MD  Guillermo Carbonell MD  Sara Lewis MD  Paul Kennedy PhD  Thomas D. Schiano MD  Swan Thung MD  Aaron Fischman MD … See all authors 

First published: 19 February 2020 https://doi.org/10.1002/jmri.27087

50)  RSNA

Radiology: Imaging cancer

Assessment of Hepatocellular Carcinoma Response to 90Y Radioembolization Using Dynamic Contrast Material–enhanced MRI and Intravoxel Incoherent Motion Diffusion-weighted Imaging

Stefanie J. Hectors, Sara Lewis, Paul Kennedy, Octavia Bane, Daniela Said, Maxwell Segall, Myron Schwartz, Edward Kim, Bachir Taouli 

Author Affiliations

Published Online:Jul 24 2020https://doi.org/10.1148/rycan.2020190094

51)  Diagn Interv Radiol. 2020 Mar; 26(2): 74–81.

Published online 2020 Jan 2. doi: 10.5152/dir.2019.18366

PMCID: PMC7051262

PMID: 32071025

Quantitative assessment of diffusion kurtosis imaging depicting deep myometrial invasion: a comparative analysis with diffusion-weighted imaging

Jia-Cheng Song, Shan-Shan Lu, Jing Zhang, Xi-Sheng Liu, Cheng-Yan Luo, and Ting Chen

52)  Magnetic Resonance in Medicine.

Evaluation of hepatic steatosis before liver transplantation in ex vivo by volumetric quantitative PDFF‐MRI

Gen Chen  Jipin Jiang  Xinqiang Wang  Min Yang  Yalong Xie  Hui Guo  Hao Tang  Lifen Zhou  Daoyu Hu  Ihab R. Kamel  Zhishui Chen  Zhen Li

First published: 16 November 2020 https://doi.org/10.1002/mrm.28592

53)  Book: Diagnostic imaging and image guided therapy for renal tumors

Tim van Oostenbrugge

Chapter 2

The role of kidney tumor diffusionweighted MRI derived ADC histogram 

parameters and added value of tumor volume and patient characteristics to 

discriminate oncocytoma from renal cell carcinoma

T.J. van Oostenbrugge, I.M. Spenkelink, L. Bokacheva, H. Rusinek, M.J. van Amerongen, J.F. Langenhuijsen, P.F.A. Mulders, J.J. Füttere

54)  Academic Radiology

Volume 28, Issue 3, March 2021, Pages e77-e85

Prediction of Platinum-based Chemotherapy Response in Advanced High-grade Serous Ovarian Cancer: ADC Histogram Analysis of Primary Tumors

Author links open overlay panelJingLuMDaHai MingLiMD, PhDabSong QiCaiMD, PhDacShu HuiZhaoMD, PhDadFeng HuaMaMD, PhDaeYong AiLiMDaXiao LiangMaMDaJin WeiQiangMD, PhDa

Build 400 is released.

 1. VK_F9 now activates :  Set Projection for this View function.,

2.  Added Slab thickness field to the SetProjection dialog box

3. FVX format v.15 is introduced (due to the change inVA_VOLPROJ structure)

4. VolumeProjection dialog: implemented new functionality {MinIP,MaxIP,AvgIP| with the User-specified Slab thickness. Works on all projections of {UINT,REAL} volumes.

5.  ConvertVolumeRealToInteger:  added parameter Bias and completely parallelized. This function is used in DICOM load.

6.   When DICOM folder contains the files with the duplicate SOP Instance UID, User is given the option to delete the duplicates.

7. New UI function :  MainManu>Measure>Polyline length

Build 399 is released.

 1. Internal : DetectRidges function (principle in MR\CT lung segmentation):  code optimization  and switching to AVX256 led to X4 speed up.

2. Internal: Convolution2D function, when PadDuplicate=false now chooses the lowest value for the entire Volume (previously =0)

3. Ensured that the CT lung segmentation works when Volume is loaded as REAL (HU)

4.When displaying cursor voxel value over the real volume check if the signal is pseudo-real and display the integer format instead.

5. When loading DICOM volume and negative voxel values are present - offer to load as UINT with the bias

 FireVoxel Build 398 is released.

1. Developed a compression scheme for the pseudo-real volumes (Signed integer volumes represented as REAL).  Compression 1:1 matches the corresponding ratios for SINT files.

2. Removed the DICOM load dialog for choosing between the REAL load and UINT load with the bias. Loading of CT files is now done the same way as Mango and 3DSlicer.

3. Rigid HU display on the status bar is removed and HU units are properly displayed.

4. IsMatchingVolume function : extended for quasi-precise comparison with MaxAbsDiff measure and specified Eps tolerance.

Build 397B is released.

 1.  DICOM:  supporting the JPEG RLE decoder now

2. Further adjustment of the logic when loading DICOMs with the resulting signed integer voxel values.

 Build 397A is released.

1. Post-Build corrections related to the new scheme of loading the DICOM files.

Build 397 is released.

1. Reimplementation od DICOM loading logic when the PixelRepresentation type=1 (Signed Integer).

2. DICOM loading dialog (SINT case)  - User now specifies bias only, simpler logic.

Build 396 is released.

1.  Dynamic Experiment : implemented new functionality when there are several ROIs are present and the Voxelwise processing is requested (Process All ROIs voxelwise). Each ROI is processed separately and resulting parametric maps are combined for each output parameter.

2. Dynamic Experiment: internally save parametric maps to layer directly RAM->RAM (avoids the legacy RAM->IM_FILE->RAM construct).

3. Optional DoProgress for Load FVX document.

4. Implemented the Batch Parametric Modelling on the folder of FVX files.

Build 395 is released.

1. Fixed various misspellings in Concentration Conversion dialog box.

2. RoiStats3D : fixed Entropy (nats) display issue.

3. Fixed defect in Transform>MirrorX on REAL volumes.

4. LayerControl dialog:  when the Layer is removed, we check and see if the removed volume was Active.  If not, the Active volume remains the same.  Active = 0 otherwise.

Build 394E is released.

 1.  Workflow>Lung (MR)>4D Both Lungs Segmentation using FLEXR MC

added a UI function to segment both lungs in one run, making it easier to process.

2. Processing of 30 lung cases for ISMRM, adjusted the format of lung reports.

4. Volume->Concentration Conversion using T1 map:  fixed the NAN issue that was causing a crash.

     ROI is operational now, so the processing is limited to ROI now.

5. Removed unused function in FvxLoadSave.cpp

Build 394D is released.

 1. 4D Lung single slice ROI segmentation : provided a separate function under Workflow>Lung (MR) menu.

2. Implemented the UI UserOptions checkbox item "Compress DICOM headers when saving to FVX document".  This allows to optionally avoid DICOM compression

Build 394B is released.

 1. WML segmentation : Fixed an issue when supplying an external GM layer.

Build 394A is released.

 1. WML-FLAIR-MPRAGE segmentation: added ability to supply an external Gray Matter mask. Updated the dialog box accordingly.

2. Fixed defect when writing the current version of the FVX file (current = V14)

3. Workflows>Lung>Single Slice segmentation :  fixed the orientation problem when L & R were swapped.

FireVoxel Build 394 is released.

1. Lateral Ventricle segmentation : Updated end expanded parameter set, updated the dialog box.

2.  WML segmentation from (FLAIR+MPRAGE):  updated the algorithm to deal with the hollow lesions (GM oversegmentation).  Updated the dialog box.

3. Fixed crash problem with the FLOAT32 NIFTI image.

4. Fixed the defect "Change Resolution New Dimension" support function

5. Implemented new function :  MainMenu>Transform>Change resolution

6. Implemented a new version of FVX file format (#14).  It compresses all the internal DICOM headers together.

Build 393 is released.

 1.  ROI Inflate function (using DrawVic) - parallelized for x4 speed up.

2.  Fixed a "non-initialized memory" defect. When .IM file was loaded the ImagePosition was not initialized, so when it was not 0 - it lead to the resolution calculation failure.

3.  DICOM image crash : fixed situation when sequence element is present but does not contain a value.

4. Implemented the new BiModal Histogram Split dialog (allows both Peak Ratio and optional Mass Ratio)

5. Implemented new Histogram segmentation methods {BiGauss,BiLaplace} ratio constrained including optional mask ratio.

6. New version of WML segmentation tool (from FLAIR+MPRAGE) with the updated GM segmentation based on Mass ratio.

7. Volume registration using DICOM tags:  fixed the defect so that the resulting layers have ViewFilter and the Mark identical to the source layers.

Build 392B is released.

1. MainMenu>Measurement: MutualInfo  : works now on 4D volumes, or a combination of 3D and 4D volumes.

Build 392A is released.

 1. Fixed opening of the Ultrasound DICOM file. This was due to the presence of the VR_AT attribute.

2.  Individual measurement of the Mutual Info (under Measure) menu:  removed multiplication by (-1) which is used in registration task context.

3. Measurement MI: Fixed improper memory free that was causing a later crash because images were deallocated.

4: Dynamic Analysis: Calculate Cross4D Mutual Info items:  moved to under the Measurement Menu.  Removed the (-1) multiplication.

Build 392 is released.

 1. Fixed: Background voxels in NII are assigned value which is Not A Number (NAN = i.e. sequence of bytesthat have no meaning as a floating point number). 

So FireVoxels loads those voxels as VOID.  User has an option to save it back to NII, than FVX shows the dialog "Replace VOID voxels with X".

2. Histogram segmentation:  removed PVV and Zigalga methods from the User interface. They are still used in legacy workflows.

3. Integrated the Gaussian Mixture Models c++ code.  Exposed the GMM model as the HIstogram Segmentation.

4. Removed the PVV and ZIGALGA methods from User Interface.

5. Fixed the crash: Loading a {ANALYZE,IM} file, VROI, Crop.  This was due to the missing Dynamic Coordinates.

6.  AutoFocus4D dialog box. Performed adjustments, removed the Ensemble algorithm option and corresponding fields.

7. Layer Control dialog: "Remove layers" operation: added a check when all layers are unmarked to prevent crash.

8.  Transform>Rotate Orthogonal  :  now transforms all the layers of the Entity.

9.  Transform>Rotate Orthogonal  :  updates the orientation of the new volume correctly..

9. VROI on multilayer entity:  automatically selects the layer with MaxT for use in VROI.

10. Enclose connected component by the VROI now automatically generates the VROI name.

 1. Volume ROI Bit Operations: fixed the crash when non-ROI volume is supplied. Displays an appropriate diagnostics.

2. Updated version of the WML segmentation algorith: added 2 heuristics:

a) sulci of certain depth are excluded

b) narrow isolated channels inside the brain are treated as sulci and are excluded.

3.  Implemented new GUI function : ROI>Morhphology>Extract Holes 3D

4. Corrected a "Lock out" defect in EdgeWave: when the ROI layer is the source operand and the "Average over Seed mode" is default in the parameters, the EW dialog would not appear and inform "invalid operand for this operation".

5. Fixed UI problem:   Brain Segmentation UI used the same parameter variable as the general EdgeWave item. This was causing problems in some complex workflows.

6. Implemented  new UI functions:

Common task, having volume in native projection X, reslice it to a new document in 

one of the major projections {AXIAL,SAGITTAL,CORONAL}

7.

In SetProjection dialog box added 3 buttons to Rotate to major projections  (depending on the UserOptions  RADIOLOGICAL\NEUROLOGICAL )

8. 

Added a function to make current projection -> Native.

9. Implemented "Lateral Ventricle Segmentation" including the respective dialog box.

10. Fixed defect: All Rotations under Transform menu: the Alpha of new layers = Alpha of the original layers now.

11. Moved WML functionality to under the Workflows>Brain MR menu. Kept a single function since it works for all native projections.

12. Added the built-in N3 to WML FLAIR workflow.

13. Developed a stand-alone dialog for WML FLAIR segmentation.

FireVoxel Build 390 is released.

1. Dialog VolumeInfo : Implemented sorting of the DICOM Info by columns {Tag,Name}

2.  Dialogs VolInfo,OpenDicom : added the "Sequence>" prefix for the Sequence descendants.

3. All dialog boxes in FireVoxel:  updated capitalization according to MS GUI guidelines.

Build 389 is released.

 1. VolumeINFO dialog box:  The multi-column info Panel is available for full content retrieval in Notepad through the CopyInfo function.

2. Implemented the Sorting of the DICOM Info {Full,Quick} in the Dicom Open dialog box.

User can press either on Tag or Name header button and it will be sorted.

 FireVoxel Build 388 is released.

1. Open DICOM dialog box.  The info Panel is available for full content retrieval in Notepad through the CopyInfo function.

 1. Dynamic Model 3: Modified names of the output parameters to match the UI timing convention.

2. Major update to NIFTI  Import\Export to fully support the IMAGE_POSITION_PATIENT.

3. If NIFTI Load: fixed the loading of invalid NIFTI files so there is no unlimited loop.

4. Support loading of the incomplete DICOM files with critical tags missing and allow ROI drawing over it.

5. Transform: Orthogonal Rotation: resulting volume is always in "Native" projection now.

Build 386B is released.

1. Fixed defect:  "a tricky DICOM file size 256x256 but it contains an "Unknown" sequence which contains the Columns*Rows = 128x128.Few Builds ago we became more diligent about sequences (remember Louisa's bolus\contrast subsequences). So combined with that file, it makes FVX confused."

2.  FIXED: crash:   while trying to transform 4D volume with SectorRotate\VectorTranslate function. This particular function requires a separate Affine matx for each timepoint. But I was only providing a single matrix to the API.

3. FIXED issue: "When polyline\spline is drawn on non-native projection the FVX file does not remember that projection for polyline\spline object is now shown on the reload. FVX file format was modified for polyline objects (of course all old files will be supported)

Build 386A is released.

 1. Main Menu>Measure>Mutual Info over optional ROI:  now supports 4D volumes.

2. Updated the breast BPE tool report so formatting is suitable for Excel.

 Build 386 is released.

1. Implemented Workflow>Breast BPE maps>Motion correction.  Based on FLEXR a call optimized for motion correction in 2D+t volumes.

2. Implemented BPE Map generation and report.

Build 385B is released

 1. 4D-ROI Volumetric Measurement dialog box: fixed "Copy Curves" functionality to include the Time info and to open the Notepad.exe.

2.  Elongated object measurements:

a) Start-to-End distance in mm reported.

b) 4th column: for each point of centerline a sum of distance to Start and End.

3. Implemented UI function:   >Measure>Mutual Information between 2 layers

4. Curve analysis:  implemented a function to determine "Periodicity" of the curve. Integrated withing the lung workflow.

Build 385A is released.

 1. Remove the Test>ROI Longest Axis Centerline function from UI

2.  Workflow>Pancreas>Longest Axis:  text report now includes the name of the original document.

3. Lung Spirometry FEV1 : modified algorithm for noisy curve, so no negative values are allowed.

4. 2D Lung spitometry: modified curve analysis process so the peaks and bottoms are identical for L&R curves.

5.  Added ABT subtest for the FLEXR- MC Segmentation procedure.

Build 385 is released.

 1. Implemented prototype of Lung diaphragm movement detection and display.

2. Fixed the defect: Crop current timepoint in 4D volume was sometimes causing a crash.

3. Developed new segmentation algorithm for 4D Volume segmentation based on FLEXR-MC.  User draws organ ROI on the first timepoint and the procedure segments\registers that ROI on all remaining timepoints.

4. Fixed defects inside the FLEXR-2D algorithm.

5.Processed 8 patient cases for lung exam 2D+t, developed the Measurement reporting to characterize the lungs.

6. Defect fixed:  In ROI stats4D dialog when saving the TAC or copy clipboard, the signal value output was always positive (abs).

7. Defect fixed: when 4D volumes (without ROI) generates a parametric model in "As a single curve" mode, Report is pressed and the crash occured.

8.  Fixed situation: when NIFTI image file contained NAN FLOAT32 (not-a-number).  Such voxels are assigned 0 value instead so the loading could proceed.

 FireVoxel Build 384A is released.

1. Implemented new workflow item :

 MainMenu>Workflow>Pancreas>Measurement along Central Axis

2. For pancreas, the start of the axis is assigned to the End with the left-most coordinate. Provided an API for custom Axis Start logic.

3.  Axis measurement tool outputs text report that contains both the name of main layer volume and ROI.

Build 384 is released.

 1. Developed procedure to detect local Min/Max in Spirometry volumetric curve.

Note filled circles here designate the Peaks and Trenches of the volumetric curve.

2. Developed procedure to fold the spirometry lung volume curves into a single average cycle. Provided a specialized dialog for it.  Dialog allows to switch between "Full curve" view and the "Cycle-only" view.

3. Added options to Lund Function  dialog to display {Full Curve, Cycle, Inspiration, Expiration} curves.

4. Fixed the defect when loading the FLOAT32 .NII file resulted in the volume be uniformly = 0.

5. Updated internal NiftiToDicomOrientation function.

6. Developed a Free-knot Spline approximation for the Function graphs. Was applied to the Lung curves (both Full and Cycle).

7. Modified the Binary Load for the NIFTI   FLOAT32/FLOAT64 files to detect if the file is actually an ROI.

FireVoxel Build 383B is released.

 1.  Fixed the crash when cropping a single slice from a 2-layer document and there is a resolution mismatch (was caused by a negative SPACING_BETWEEN_SLICES, with negative being legal under DICOM).

FireVoxel Build 383A is released.

 1. Corrected the mouse lag issue: specifically in Raster paintbrush, but also this improved spline function and VROI definition.

2. Raster paintbrush: corrected dialog box so the Radius is measured in (vox)

Build 383 is released.

 1. Fixed the SAVE\RELOAD defect when saving FVX document including the polyline OR spline.

2.  Added functionality to SAVE to DICOM   volumes of type FLOAT64.

3. Implemented improvements to the "Fix DICOM Tags" tool.

FireVoxel Build 382 is released. 

1. Volume Information dialog:  DICOM header is now displayed with Nesting up-to level 1 (so some sequences are shown as part of the Dicom Tree)

2. RoiStats 3D dialog:  replaced static text elements with the Edit Control (read-only,Multiline,Transparent) so that User can select and copy any text inside the dialog box.

3. Implemented a custom "DICOM Tag fix" function.

Build 381 is released.

 1. Fixed important crash defect in IsVoidVoxPresent function.

2. Modified the optional REAL loseless compression scheme getting x2-x4 compression on real PET images.

3. Reimplemented Huffman compression API for 1-byte value buffers.

4. Updated internal lossless compression for REAL images:

PET image with 60 timepoints, 400 MB of data is LOSSLESSLY

compressed down to about 50MB (x8 compression). This compression is optional (managed through UI Options dialog), only slightly slower. Also would reduce the size of the FVX file if saved.

5. Code optimization for internal compression of ROIs, somewhat higher speed possibly will be noticeable while drawing on ROIs on slower computers.

6. Pancreas axis segmentation: added the centerline length info to the output and the Clipboard Output.

 FireVoxel 380A is released.

1. Pancreas ROI segmentation: updated the algorithm to reduce the small starting generations in Wavefront segmentation.

FireVoxel Build 380 is released.

 1.  FVX file load\save: added extra diagnostic into the Polyline object loading.

2. Set Orientation\Position dialog.  Corrected behavior of "Align to Scanner" when the original orientation is undefined.

3. Removed redundant design from the Orientation\Position dialog box.

4. Implemented first prototype of the Pancreas segmentation and measurement tool.

Build 379 is released.

 1. Volume>Change voxel values   menu:  changed the "Transparent" item names to "VOID" to reflect exact meaning.

2.  When volume is saved to {NIFTI,MIDAS.ANALYZE}, the volume is tested for having VOID voxels and if so the User is asked for the new value to replace void voxels.

3. All AutoFocus registration function:  fixed defect when the opened Layer Control dialog would not correctly update after the registration.

4. AutoFocus 4D registration: Fixed crash defect when no Target ROI is present.

Build 378A is released.

 1. Fixed the defect when loading NIFTI images of FLOAT64 data type.

2.  Replaced the ROI "Inhomogeneity" in various locations by the "Coefficient Of Variation"

 1. Introruced new prototype function :  "Elongated ROI median axis segmentation" that provides slices along the median axis.

2. Implemented FVX file save verification.

3. Nifti: implemented code to support the negative values in INT8, INT16, INT32 (old version was truncated). If negative value is present we represent volume as REAL.

4. Nifti: implemented code to support  SLOPE\Intercept (old version was ignored). If non-trivial slope\intercept are present, then we represent volume as REAL.

Build 377 is released.

 1.  New way of saving IMAGE file:  there is NO *.time option now. Instead user selects the {.IM,.IMG,NIFTI} extension and the .TIME file is created implicitly.   This way there is no need for the second dialog to specify "4D Flavor" (MIDAS,ANALYZE,NIFTI)

2. Fixed defect in loading the VTF file (saving was done as UNICODE, but loading was done is ASCII, so defect was happening).

3. Fixed layer problem in AutoFocus3D registration.

4. VROI file:  changed both Load\Save to UNICODE text file.

Build 376 is released.

 1. Implemented NIFTI4D save as a single file with the supplemental *.TIME file.

2. Fixed defect MainMenu>Measurement>Two Volume RMSD (crashed when Volumes were 4D)

3. Fixed crash when Paintbrush outside the image.

Build 375 is released.

 1. Fixed crash in Registration>Landmark+AutoFocus.

2.  Modified function , provided new UI for the Lung MRI 4D Single Slice processing.

3. Fixed defect:   when creating VROI in multilayer document, the possible Time Interval for the VROI is now defined by the ActiveVolume (before it was MainVolume)

4. 4D registration and Motion Correction function are now displaying the VTF4D file after the execution which could be saved afterwards.

Build 374A.

 1." InterVolume edge constrained smooth" item was moved to under Test menu.

2.  Certain NIFTI files were causing the sporadic message during loading  - removed

Build 374 is released.

 1. NIFTI file load:  fixed defect when the sform_code was improperly handled. Added the diagnostics message.

2.  NIFTI file Save: fixed defect when sform_code default was=0 (but it it invalid).  Now changed to default=2)

3. Enable the load of *.TIME file associated with the NIFTI4D file (either .nii or .nii.gz)

FireVoxel Build 373 is released.

 1.  Volume>Adaptive threhold function :  renamed and moved to ROI>Local Otzu Threshold to ROI,

Code is fully reworked and now works on {INT,REAL} volumes. Dialog box for a single parameter is added.

2.  Volume>Voxel Value Conversion>Flatten Histogram  is renamed Equalize Histogram.  Algorithm is changed to match the classic description of Histogram Equalization algorithm.  Works only for 3D Integer volumes.

3.Volume>Voxel Value Converison: reimplemented the function so it works on all volume types {ROI,INT,REAL}. Added progress indicator.

4.  REDO functionality:  fixed defect so that the ViewFilter is properly restored after REDO.

5. Registration>Landmark registration  : corrected defect when there is mismatch in the number of landmarks the diagnostics was improperly displayed.

6. Changed the definition test for the "empty landmarks". Removed automatic deletion of "emptty landmarks" from Landmark Registration.

Build 372A is released.

 1. Modified Texture Edge Detector dialog : Threhsold units are now properly marked.

2.  Volume Menu:  changed the item from "Multiscale Texture Gradient 4D Aggregate" -> "Multiscale Texture Gradient 4D Max"

3.  Undo\Redo architecture:  corrected the design so not only the pixel data is saved in the UNDOREC but also the corresponding VIEWFILTER settings since the operations usually followed by  the change to the VIEWFILTER (f.e. after smoothing).

4.  Volume Dynamic Smoothing:  fixed defects

      a) Smoothed correctly along the dynamic dimension (before across time only)

      b) Correctly accounted for VOIDVOX presence.

5.  DICOM Folder browsing: removed legacy restrictions on the allowed DICOM extensions. This was redundant, because further checks are done for DICOM header. Now any DICOM extension is allowed.

Build 372 is released.

 1. Volume Edge-constrained smooth : Fixed the "crash" and changed the progress report to individual timepoints.

2.  Volume : Smooth (over Optional ROI):  extended so it works with volumes containing VOIDVOX.  Also unified processing so all the possible kernels are working from the same code.

3. RoiStats4D dialog box initialization : Corrected crash defect

4. Mutiscale Texture Gradient 4D aggregation: restored the functionality based on the common code with MSTG.

5. Volume Menu:  replaced "Texture Gradient" with "Single scale texture gradient".

6. Corrected Voxel weight scheme naming to "Rayleigh" in multiple locations

7. Volume>Voxel Value conversion>Linear Conversion over ROI : enabled UNDO for this operation.

8. In Volume menu ensured that ALL Operations modifying an existing layer are backed by UNDO\REDO mechanism.

Build 371 is released.

 1. Fixed the crash error in (Optimal Window Center Width). Error first appeared in Build 369A.

2.  Implemented a MEMFILE structure.  Similar to the standard constructs in VC++ and Linux but adapted for FireVoxel needs. Allows to write to a FILE (which is MEMFILE and resides in memory).

3.  Upgraded the FVX Save function to work through MEMFILE first and then transferring MEMFILE to a disk file at once.  This should be especially beneficial for the Remote Drives.  Also, it provides a very clear indicator of SAVE progress for large files.

4.  File>DICOM>Dicom Folder Total Pixel size function:  corrected calculation for the files without the compression.

5. Corrected wording in the dialog of the "Specify Signal to Become transparent" function.

6. Fixed the typo in "New value for transparent signal" dialog.

7.  Fixed diagnostic messages for various scenarios under Volume>Volume Type Conversion>ROI to INTEGER.

8. Dynamic Experiment dialog box (Model16) : corrected various naming issues.

9. Fixed various naming issues Model 26 and 50.

10. Corrected various naming issues in Models 24 and 25.

Build 370A is released.

 1. Added more diagnostics to FVX file save function when the target is the Remote drive.