Latest DCDI approach to  Arterial (Ta) and Venous (Tv) delay approach   was tested:

Arterial delay is defined graphically (at the moment) by analyzing the AIF and  roiTAC.
(blue-AIF,  red-VIF, green-roiTAC)

Define:   Ta = ContrastArrivalTimeROI - ContrastArrivalAIF.
For this specific ROI it was Ta = 16 sec.
At the moment User punches in this time delay, but will be entirely automatic later.

Then we perform 5 parameter fitting of DCDI model  {TotalFlow,fa,Ki,Ve,Tv}.  We set  Tv=[0,8] seconds.

Result is encouraging, with fa=0.33.  (Blue is the data curve, black is the Model curve)

ROI was made very small to avoid the blood vessels.