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Monday, March 24, 2014

FireVoxel Build 134 is released.
Fixed defect and crash:  Dialog RoiStats4D, in multilayer entity, if there are several ROIs present and if one of them is empty, no stats would be displayed even if it was not an active ROI.
Finalized the Release Candidate for Liver DCDI model. All the concentration options discussed are included. This would appear in Build 134.

Thursday, March 20, 2014

Liver DCDI:  revisiting the Monotail concept (AIF=VIF with t>3 min).  This might allow to perform a segmented fir for {F,Ve} only for this part of the curve thus stabilizing the kit.  This does not make any assumptions about the delays {Ta,Tv}, i.e. would work for any delays. Interestingly, Ki also can be derived as it is not an independent variable of in the trio of {F,Ve,Ki}

Wednesday, March 19, 2014

DCDI model:  added an User Interface option to select Linear (=1) or Logarithmic(=0) concentration conversion.
FireVoxel Build 133 is released.
DCDI model:  added an User Interface option to use the L1 or L2 metric for calculating the
fitness residual.
YL-case,   "DCDI - Stabilized V1"

Obtained a good fit with good parameter values except for the high flow. Perhaps high flow can be explained by the concentration conversion.
Note1:  ROI was drawn fairly large as in Sourbron's paper (i.e. 40-60 mm diameter)
Note2:  As in Sourbron's paper the Arterial delay exceeds the Venous delay.  Interestingly that would
mean that venous contrast arrives first, but this is exactly his primary mode.

Tuesday, March 18, 2014

Implemented automatic matching BATs of AIF and TACs. Result is inconclusive as fitting is very good but parameters are unrealistic.
Corrected the VolSetSlice function, in the binary (1-bit ROI) case.  The Source buffer was modified in this function causing the error.
New DCDI variant:   after BATs are matched, the arterial flow Fa can be calculated from the short initial period.

Monday, March 17, 2014

FireVoxel Build 132D is released.  This fixes the problem with MTT in the "DCDI  Stabilized-V1" model.

Sunday, March 16, 2014

Dialog RoiStats4D: added a function button-"BAT". When user press this button the current time advances to the BAT for this curve.
Developing an automatic  BAT (bolus arrival time) function for dynamic studies.  At the moment it will be employed in the context of DCDI model:   BAT of AIF should be matched to BAT of ROI to determine the Arterial delay specific to the given ROI.
Quick FireVoxel Builds 132B, 132C are released reflecting the urgent work on the stabilization of the Liver DCDI (Dual compartment dual input models).
Particularly, in 132C, a "DCDI Stabilized - V1" is introduce.  It uses the integral form of DCDI equation to eliminate one of the independent optimization variables thus stabilizing the fit.

Friday, March 14, 2014

Implementing the "Liver DCDI  Monotail" model that allows to avoid an explicit calculation of {Ta,Tv} (arterial and venous delay).  As the first stage only 3 parameters are calculated {F,Ve,Ki}.
FireVoxel Build 132A is released.

Thursday, March 13, 2014

Investigating defect of Saving\Loading RAW  (*.im\MIDAS) files.
Liver DCDI model:   removed the "Ve max" (extracellular volume limit) from the user interface since it is always in [0,1] range.

Wednesday, March 12, 2014

Dialog RoiStats4D:  added the Info button so the Information could be displayed more conveniently for the user.