AutoFocus 4D dialog box:  fixed the Slice Mode combo (drop down) box.

Liver DCDI:  added automatic Build Test.

There is a substantial change in FireVoxel document format in Build 130.  Added the handling of cases when user tries to load an older version of the format and an appropriate message.

Layer Control Dialog\Load RAW.  Added the function so that the *.time files can be loaded.

Fixing the design: In various part of the FireVoxel there is an inconsistent treatment of time values.  Certain structure hold time in "Absolute format" (i.e. seconds since Jan 1, 1900), other structures keeps them in seconds since the start of acquisitions.  This causes several glitches, f.e. during transfer of the Input function, from Automatic IDIF finder into Parametric Model calculation model.
Presently converting all the internal structure into the "Absolute format".  Relative times would only be constructed temporarily for specific purposes such as Display and during the Parametric Model calculations.

Defect Corrected:  When saving the TAC such as Input Function from ROIStats4D dialog box, the TAC name was improperly formatted and later incorrectly displayed inside the Parametric Models dialog.

Updated the layout of the Dynamic Experiment\Parametric Map calculation dialog.  Added new relevant buttons.

DCDI Liver mode: Performing yet another rearrangement of the variables.  Principal part is to have the S= ETS (extracellular transit speed) = 1/EMTT= (Fa+Fv+Ki)/Ve

Goal is the 100x times speed improvement during the Grid-search part of the optimization.  This can be achieved by using the ETS as the top variable of the nested loop. In that case all the exponential tables can
be precalculated once for each value of ETS.  Exponent calculations take about 99% of calculation time.

This is very relevant to plans to calculate the maps for the whole liver.

Performing rearrangement of Sourbron's DCDI equation, moving to new
optimization variables:


1. ETR = Ve/(Fa+Fv),
2. F = (Fa+Fv) ,
3.  fa = Fa/(Fa+Fv),
4. H = Ki/(Fa+Fv)

This might have definite advantages, due to simplified parameter ranges.
ETR is closely related to EMTT (extracellular mean transit time) and is in [0,100] sec interval.
F  is the total Inflow.

fa and H are just coefficients and should be in [0,1] range.

This seems to be a definite improvement over the {Ve,Fa,Fv,Ki }  variable set where all 4 nontrivial
intervals are required.

Calculated the Hepatic Uptake rate (Ki) for 2 patients. This is a very early and preliminary result.  Both maps use the same color scale. The units of measurement are "1/100/min" as per Sourbron's paper.

Implemented derived parameters as per Sourbron's paper.
Primary optimization parameters are Fa,Fv,Ve,Ki.
So far there was no need for the "Arterial Delay" as Henry had foreseen.

Performed DCDI calculation for two patients LP and KA.  Below are the "Total Inflow" maps (=Fa+Fv).  Color mapping is using the same color scale (see color bar on the right)

Liver DCDI modelling function is fast enough to process large ROIs on the voxel-wise basis
Below is the parametric map Arterial Flow (Fa) in  "ml/min/100ml" units as in Sourbron's paper.
Total calculation time is about 3 sec.

Liver DCDI model: 
a) Fully parallelized the "Grid search" preceding the iterative Amoeba  (Simplex) optimization
b) Integrated the Parallel Amoeba variant

Obtained first fitting result for the Liver DCDI model (Sourbron).
In this example 2 input functions are shown in Signal intensity units.
The target ROI is in red.
Fitted Concentration Curve (black) is overlaid on top of the Data Concentration Curve.
Optimal parameter values are shown at the bottom of the diagram. They are normalized
to Sourbron's unit from the paper and on a quick comparison are of the same order of magnitude.
Note:  Arterial delay of "0" was used.

Running tests of the Liver DCDI model, debugging and targeting the visualization of the model fit as the next waypoint.

DCDI (Dual Compartment Dual Input) model:  Implementing a fitting model, within the FireVoxel Dynamic Framework...

Implemented a support function, that in Play4D -  ALL the documents that have a compatible dynamic information will be played simultaneously.  This is very helpful for the displaying results of 4D registration,

In preparation to release Build 130:  Restoring several parts of the Automatic Build Test that use the .FVX file format. Format was changed recently due to the use of the new 3D Volumentric primitives.

Dialog "Split ROI by Threshold":
Implemented a feature, so user is able to enter the desired threshold manually.