"IVIM-Segmented"  model:
We try to investigate a suspicious peak in the histogram of the fitted Dp-parameter.  This peak occurs at Dp=0.03.  In the screenshot below one of such voxels was identified and processed individually.

Green-data curve.  Black - fitted curve.

For finding the Dp component we run the Global Optimization with parameter Dp be restrained to the [0,0.03] interval.  So optimal solution is found to be on the borders of that interval, i.e. Dp= 0.03.
Many such voxels within the ROI contiribute to the "suspicious peak".

The problem does not seem to be restricted to the cases of air/tissue partial voxels.
My current guess that this is common to the voxels where signal curve is not monotonous.

Here is anther case with Dp=0.03

Next experiment, I vastly increased the Dp-constraint interval to [0,1] and ran it on the same voxel.  Interestingly the result has settled on Dp=0.67 with 3 times lower residual.  This indicates that we have found an actual optimum.

Fit with Dp=[0,1] allowence. This settled at Dp=0.67

CONCLUSION:  seems like the presence of the  Dp- histogram tail peak is due to the restriction of the Dp=[0,0.03] during the optimization.  I will be relaxing this restriction to Dp=[0,1].
My best guess that the "presence of the histogram tail peak" is not related or causing the difference of the results with other software.  I use the Global Optimization which is very different from Local Optimization used in other software.  To my best knowledge the FireVoxel fits are valid and excellent (judging by the residual). So my best guess is that "other software" is not fitting well enough.

Here is the histogram of resulting Dp values with  Dp=[0,1].  Previous strong peak at Dp=0.03 is gone. My best guess: these high values due to some voxels having strongly monoexponential signal
curve.

We can get to the bottom of it if I send a single Signal Curve, along with FireVoxel-calculated parameters and residual.  Then curve can be processed in "other software", residuals compared and so on.

On Mouse Move - Display voxel information:  fixed a defect when the Active Layer is disabled, so moving the mouse did not produce any information in the status line.
Now if the Active is disabled, we choose the First enabled layer to display the voxel info.

Synchronize Multiprojection Cursor (mode=ON) functionality:  if there is a single View\Projection of the volume is visible the Crosshair cursor would not be visible.

BuiCal nonuniformity correction over the set of 12 "Sodium"-images.

To precisely evaluate the effect of the correction, 15-20 seeds were precisely and manually constructed on each of the cases.  All of the seeds were positioned inside of the ventricles as far as possible from the edge of ventricles and corresponding partial volume voxels.

Non-uniformity is defined as the StdDev of the average seed signal taken over all the seeds.

Seeds are in Red on one of the slices 

We tried to find set of parameters that worked well on every single image.

See the Table of results below for each case  

1st column:  Case name

2nd Column:  original non-uniformity (StdDev over seeds)

3rd Column: processed non-uniformity (StdDev over seeds)

5th column relative improvement of the correction =NUbefore/NUafter-1

Interestingly the results for N-cases where 10 times weaker than the results on "Non-N cases", 6% and 61% improvement correspondingly.

N3 correction was attempted but NU only worsened with all the parameter combinations we tried.

Overall these images are quite challenging for Non-uniformity correction, due to the low resolution and the ventricles being only 3-4 voxels thick.  Note the original .NII files contained the resolution of (1,1,1)mm but this does not seem to be the case,

BiCal on Sodium images: fixed the defect when iterations of BiCal were producing a "better" result.
This was due to the custom scheme of processing the REAL images, when internally they were converted to the 15 bit images and this was conflicting with the internal truncation mechanism after the correction.

Sodium image for testing the BiCal non-uniformity correction.  NII file resolution is listed at 1mm^3 (dimensions are 128x128x128) but it seems incorrect.  User desire the signal in ventricals (see the seeds) to be uniform.

Build 208   is released.

1. IDIF function: Fixed the "invalid rectangle" defect exhibited on P1.fvx.  This was due to the inflated initial rectangle to be outside the image bounds.

2. Implemented an order-of-magnitude CountBits( PBYTE Array,int Start,int End) function which is frequently used throughout.

3. Dynamic Modelling (models {0,3}): fixed the user defined parameters for starting dynamic index to 1 (from 0).

4. Dynamic Modelling framework fix:  When PET image is processed with "Process ALL", i.e. without the ROI, the dialog box was popping up asking to specify T1.

5. Dynamic Modelling:  added a test for Tissue Concentration if the Modality=PET. In this case the Concentration Method is always set to "SIGNAL" and user is warned.  This is done in addition to an earlier implemented check for the Input Function in PET.

6. Dynamic Model "Input function correlation": Added a proper handling of the Tissue concentration. Before it was "Signal only" and created inconsistencies for the user.

7. Dialog Layer Operations: fixed crash defect related to the Entity Layer upgrade to 22 layers in the previous builds.

8. Fixed the error in reslicing binary volumes (ROIs).  Old procedure was always assuming the FillVoid or Background value is always '0' but this is not correct always.  This was detected in "Reslice Target to Source" option during the Femur registration.

9. Dynamic Modelling:  Input Function correlation: corrected the situation when the divisor n*XX-X*X or n*YY-Y*Y is close to zero.

10. Dedicated menu item was added to the workflow menu with the parameters suited for processing.

11. LayerControl dialog: updated behavior so that the Name editing requires Doubleclick, while "ROI advance to midslice" requires "Ctrl+Doubleclick".

IDIF function: Fixed the "invalid rectangle" defect exhibited on P1.fvx.  This was due to the inflated initial rectangle to be outside the image bounds.

Implemented an order-of-magnitude CountBits( PBYTE Array,int Start,int End) function which is frequently used throughout.

Dynamic Modelling (models {0,3}): fixed the user defined parameters for starting dynamic index to 1 (from 0).

Dynamic Modelling framework fix:  When PET image is processed with "Process ALL", i.e. without the ROI, the dialog box was popping up asking to specify T1.

Dynamic Modelling:  added a test for Tissue Concentration if the Modality=PET. In this case the Concentration Method is always set to "SIGNAL" and user is warned.  This is done in addition to an earlier implemented check for the Input Function in PET.

Dynamic Model "Input function correlation": Added a proper handling of the Tissue concentration. Before it was "Signal only" and created inconsistencies for the user.

ABT :  added a subtest for basic functioning of the Layer Operations dialog.

Dialog Layer Operations: fixed crash defect related to the Entity Layer upgrade to 22 layers in the previous builds.

Fixed the error in reslicing binary volumes (ROIs).  Old procedure was always assuming the FillVoid or Background value is always '0' but this is not correct always.  This was detected in "Reslice Target to Source" option during the Femur registration.

Dynamic Modelling:  Input Function correlation: corrected the situation when the divisor n*XX-X*X or n*YY-Y*Y is close to zero.

Femur registration:  one of the scenarios to have femur ROI only on the Baseline image. So when the followup image appears to perform registration without constructing "followup ROI".
Registration using Mutual Info provided visually accurate result. Execution times are slower closer to 20 min (as opposed to 5 min on ROI->ROI).
Dedicated menu item was added to the workflow menu with the parameters suited for processing.

LayerControl dialog: updated behavior so that the Name editing requires Doubleclick, while "ROI advance to midslice" requires "Ctrl+Doubleclick".

FireVoxel Build 207 is released.

1. Dialog Layer Control: When there is a ROI layer present - user may doubleclick on the layer name.  Current Z-slice of the entity would be changed to the mid-Z slice of that entire ROI (at that current timepoint in case of 4D ROI).
2. 3D Paintbrush:  enabled the drawing with the Radius=0
3. Use Interface options dialog:  removed the "Synchronized cursor" option.
4. Dynamic Modelling:  Input Function correlation model:  fixed the bug and checked the correctness on the identity problem.

Femur registration, attempt to register without the follow-up segmented ROI.
Attempted the following scenario:
baseline Target+ROI (WALS1)  is registered with the Source WALS2 only (no ROI).

Mutual Info measure was used.  On the screenshot below you can see the WALS2 registered and then overlayed with the WALS1-ROI.  Visually appears to be a good match.
This makes it very likely that follow-up ROI would not be required for registration.

One downside - it took about 20 min, vs.  5 min on ROI->ROI scenario.

WALS2 (transformed after registration) overlayed by the WLAS1-ROI (static as the Target)

Dialog Layer Control: Major new feature and behavior change:
When there is a ROI layer present - user may doubleclick on the layer name.  Current Z-slice of the entity would be changed to the mid-Z slice of that entire ROI (at that current timepoint in case of 4D ROI).  FilmView would be always turned off immediately.

Old functionality:  before the doubleclick would bring the name edit control.  This requires now pressing the Control+Dblclick button.

3D Paintbrush:  enabled the drawing with the Radius=0

FireVoxel Build 206A is released.

Use Interface options dialog:  removed the "Synchronized cursor" option.

Dynamic Modelling:  Input Function correlation model:  fixed the bug and checked the correctness on the identity problem.

FireVoxel Build 206 is released:

1. IVIM free model fix:  was always returning "0" as the residual of the fit.
2. ABT test for Dynamic Modelling:  modified the test so that results are compared to Standard using the specified tolerance (1e-3) to avoid costly investigation into ABT trivial "red flags".
3. Mouse brain  PET-CT-Atlas workflow:  verified that workflow works with the complete 20-region atlas.
4.Produced a Mouse brain atlas of all 20 regions that can be now processed by the Layer Control dialog.
5. Expanded current Layer Control dialog to 22 layers to accommodate an entire Mouse Brain Atlas.
6. Fixed the .IM Save\Load problem
7. Implemented a very early prototype of the new Layer Control dialog box.  This Control would provide handling of all hybrid types of the primitives present in the FireVoxel entity:  {Volumes,Landmarks,VROIs,Pollygons,Text, etc}.  This dialog supports an unlimited number of layers. During the prototyping stage this dialog is activated by F9.
8. Code improvement:  moved the CDlgLayerCtrl declaration within the class source module.
9 Dynamic Modelling module:  implemented the Parametric map "Input function correlation"
10. Femur ROI registratio: Implemented a dedicated menu item with parameters suitable for this application.
11. ROI->ROI registration: Developed the Signal difference calculation working directly with Run-length representation of ROIs (x10-20 memory compact) that resulted in x10 speed up during the AutoFocus on Subscale=3. Speed up is even higher on the Finetune phase approaching

Visual Correlation (?) comparison between supplied AIF and 1-voxel ROI

note: the signal baseline in this particular dialog = 186

IVIM free model fix:  was always returning "0" as the residual of the fit.

ABT test for Dynamic Modelling:  modified the test so that results are compared to Standard using the specified tolerance (1e-3) to avoid costly investigation into ABT trivial "red flags".

Mouse brain  PET-CT-Atlas workflow:  verified that workflow works with the complete 20-region atlas.

Produced a Mouse brain atlas of all 20 regions that can be now processed by the Layer Control dialog.

Expanded current Layer Control dialog to 22 layers to accommodate an entire Mouse Brain Atlas.

Fixed the .IM Save\Load problem.  When original file (Atlas template) was provided it had invalid Unit Names for the voxel.  After Saving it to MIDAS, loading as a layer and the saving to FVX was causing the crash loading the resulting FVX file.

Implemented a very early prototype of the new Layer Control dialog box.  This Control would provide handling of all hybrid types of the primitives present in the FireVoxel entity:  {Volumes,Landmarks,VROIs,Pollygons,Text, etc}.  This dialog supports an unlimited number of layers. During the prototyping stage this dialog is activated by F9.

Code improvement:  moved the CDlgLayerCtrl declaration within the class source module.

Dynamic Modelling module:  implemented the Parametric map "Input function correlation"

Femur ROI registratio: Implemented a dedicated menu item with parameters suitable for this application.  Default parameters provide speed of under 5 min on the WALS1-WALS2 sample.
Speed is variable and defined by the precision of the AutoFocus stage (such as rotation precision and range)

ROI->ROI registration:  during the reslicing operation in AutoFocus\Finetune iteration ROIs are transformed and partial volume voxels appear while the majority of voxels still remain binary ROI. Calculating of signal difference in the obvious way was not fast enough for comparing the massive images for Femur registration problem.
Developed the Signal difference calculation working directly with Run-length representation of ROIs (x10-20 memory compact) that resulted in x10 speed up during the AutoFocus on Subscale=3. Speed up is even higher on the Finetune phase approaching x30.

Femur registration of Bone ROI->ROI using "Signal Difference" Measure.  Matching result is good but takes more than 1hr.

Build 205 is released

"MainMenu>ROI>Split ROI by Threshold" - added the BiModal Laplacian with ration method for initial split.

Enabled accelerator "Ctrl+S" :  "Save FireVoxel document"

Implemented new rule to select threshold from 2 modelled distribution:  "Minimize Missclassification" rule.

BiModal Laplacian histogram

CT-PET-ATLAS workflow: Register ALL:  fixed the crash defect on case W73"Deep breathing" lung segmentation case:  no leaks after BiCal+EdgeWave

Mouse Brain, CT-PET-ATLAS wokflow:
Provided an additional registration function to register everything to the PET space to avoid any transforms\interpolation of the principal data (PET).

Mouse Brain   CT-PET-Atlas workfow:  finished the integrated "one-click" registration function

Added the functionality to extract only desired regions from the Atlas

Landmark co-registration:
a) When Source={3D,4D} 2-layer entity, registered to a 3D-volume, the timing information of the 4D volume was lost
b) Also corrected the defect when Alpha (transparency) and the color scheme of the source were lost after the regidstration.

Dialog RoiStats3D:  in Model-based Histogram segmentation added an option to view the "Modelling Cumulative" curve  (options are {None,All Curves,Cumulative"}
Also removed the "BiGauss Explore" and "BiGauss with Ratio Explore" options since they are superceded by the curves display now.

Histogram model-based segmentation {BiGauss,BiLaplace}: Implemented initial framework to show the modelling curves overlaid on top of the histogram

Implemented some improvements to Global Optimization algorithm and code.

Fixed crash defect while loading the DICOM folder obtained from Mr. Zhang under Win10. This was due to using the 32-bit truncation in CTreeCtrl::SetItemData during the DICOM tree construction.

Moved the main development environment to Windows 10.

Fixed the defect in RasterPaintbrush dialog box:  checking the "Allow paint on parametric Maps" had no effect and setting was not remembered.  Drawing on Parametric maps is now possible.

Fixed the paintbrush problem when drawing on integer volumes.

Registration by the landmarks:  provided more detailed analysis in case of the landmark mismatch between Source and Target.  

Registration by Landmarks:  upon the start of the procedure all the "invisible" (void) landmarks are unconditionally removed from ALL documents. This is to avoid frequent confusion during the registration.

"MainMenu>ROI>Split ROI by Threshold" - added the BiModal Laplacian with ration method for initial split.

Enabled accelerator "Ctrl+S" :  "Save FireVoxel document"

Implemented new rule to select threshold from 2 modelled distribution:  "Minimize Missclassification" rule. This rule does not use actual histogram values

Further extensions are possible with histogram value usage.

We have found good BiModal match of the Histogram.  Having two curves (Gaussian or Laplacian) what is the suitable algorithm to choose the threshold?  Presently we choose the lowest point between the peaks of two components, but now I have doubts about this.  Should it be the intersection of 2 curves instead?

BiModal Laplacian histogram segmentation (first result):

This is simplistic global optimization (without extremum checking so did not perform as well as BiGaussian with the same number of iterations = 200K)

Proposed semi-automatic "breast\chest wall" segmentation:

One way is to segment OUT the chest wall, after that breast segmentation is a simple EdgeWave operation.

To segment the chest wall:
1. On every 5th slice, draw the chestwall boundary as an ROI (see pic below).  In this prototype I recommend the boundary starting and ending at the margins of the image (later on we can eliminate this).

2. I will provide a specialized operation "MainMenu>Applications>Breast>Segment Chest wall from Contours".  Internally this operation would perform completing the contour, and then "Fill & Morph convex" to fill the skipped slices.

3.  Result of this operation would be a "CHEST ROI" that could be excluded from the image.  Then we would simply apply the EdgeWave to segment out the Air.

4. Manual processing time should be <1 min.  Computing time is <20 sec.

CT-PET-ATLAS workflow: Register ALL:  fixed the crash defect on case W73

"Deep breathing" lung segmentation case:  no leaks after BiCal+EdgeWave

Some very approximate parameters for BiCal - would work in the wide range.

BiCal parameters

EdgeWave (with seed) parameters

Mouse Brain, CT-PET-ATLAS wokflow:

Provided an additional registration function to register everything to the PET space to avoid any transforms\interpolation of the principal data (PET).

Mouse Brain,  CT-PET-Atlas workflow.



1. Load Atlas once for the whole study session. Minimize the View, so it is out the way and reduce screen clutter. You don't need to open Atlas for every registration.

2.  Load CT-3D volume with landmarks present

3.  Load PET-4D volulume

(steps 2,3 in any order)

4.  Choose "MainMenu>Applications>Mouse Brain Atlas-PET-CT workflow"

5.  After brief processing only one document will remain that contains
CT,PET and several ROI layers.

6.  Press F4 to bring up the curve dialog, this might take up to 1 min since there are many ROIs present.  You will see something like below:

Mouse Brain   CT-PET-Atlas workfow:  finished the integrated "one-click" registration function.  Resulting entity is ready to get the PET curves and save them (to text file)

Prepared first integrated mouse brain Atlas with ROI regions named and the 4 Landmarks included.  This is ready for the final processing.

Added the functionality to extract only desired regions from the Atlas.  User enters the desired region indices separated by commas.  Result: they will appear as the new ROI layes named "atlas region #x" according to the specified indices.

Landmark co-registration:
a) When Source={3D,4D} 2-layer entity, registered to a 3D-volume, the timing information of the 4D volume was lost
b) Also corrected the defect when Alpha (transparency) and the color scheme of the source were lost after the regidstration.

Dialog RoiStats3D:  in Model-based Histogram segmentation added an option to view the "Modelling Cumulative" curve  (options are {None,All Curves,Cumulative"}
Also removed the "BiGauss Explore" and "BiGauss with Ratio Explore" options since they are superceded by the curves display now.

Histogram model-based segmentation {BiGauss,BiLaplace}: Implemented initial framework to show the modelling curves overlaid on top of the histogram. Notice the threshold is chosen as the midpoint between 2 peaks.

Implemented some improvements to Global Optimization algorithm and code.

Verified correct result of Histogram segmentation using "Bigauss with Ratio" method on the sample from EdgeWave manual.  BiGauss ration interval was [1.1,2]. This did not seem to work on Henry's computer.

Fixed crash defect while loading the DICOM folder obtained from Mr. Zhang under Win10. This was due to using the 32-bit truncation in CTreeCtrl::SetItemData during the DICOM tree construction.

Moved the main development environment to Windows 10.

Fixed the defect in RasterPaintbrush dialog box:  checking the "Allow paint on parametric Maps" had no effect and setting was not remembered.  Drawing on Parametric maps is now possible.

Fixed the paintbrush problem when drawing on integer volumes.

Registration by the landmarks:  provided more detailed analysis in case of the landmark mismatch between Source and Target.  List of Source mismatch landmarks + List of Target mismatched landmarks is provided.

Registration by Landmarks:  upon the start of the procedure all the "invisible" (void) landmarks are unconditionally removed from ALL documents. This is to avoid frequent confusion during the registration.

Mouse CT->Atlas landmark registration (suing 4 landmarks).

FireVoxel Build 204 is released.

1. Fixed the SaveDicom defect introduced by the DeIdentifier code.

2. AutoFocus 3D registration: when the Target volume is ROI, allow to use it as a Target ROI role two (so it serves two purposes

3. T1-EPI-PET lesion workflow:  added an option to register the whole lesion ROI at once ("3D Mode").

4. "Dialog RoiStats4D : Save Curve" function:  in case of 4D ROI added information about the volume of the ROI for each timepoint.

5. When dynamic dimension="TIME", we output the time values as a difference from the initial timepoint.

6. EdgeWave resulting layer name generation - improved with adding the name of Dynamic component in case of the 4D volumes.

7. EdgeWave on near-isotropic lung volume "shifted-y-axis" defect:  was caused by slightly different definition of "isotropic" between different software modules.

8. Defect "View Projection of the Selected Entity": fixed defect when specifying projection produced an immediate crash.

Fixed the SaveDicom defect introduced by the DeIdentifier code, so the changeSeriesUID flag was not functioning.

AutoFocus 3D registration: when the Target volume is ROI, allow to use it as a Target ROI role two (so it serves two purposes).  This dramatically speeds up registration in some cases. This was developed in the context of the EPI->T1 registration as requested as Eric.

PET->T1 breast lesion registration workflow: Corrected a default problematic parameter "ScaleGrid=0" set to 1.

T1-EPI-PET lesion workflow:  added an option to register the whole lesion ROI at once ("3D Mode"). Original slice-by-slice method is kept (2D Mode).

1. "Dialog RoiStats4D : Save Curve" function:  in case of 4D ROI added information about the volume of the ROI for each timepoint.
2. When dynamic dimension="TIME", we output the time values as a difference from the initial timepoint.

EdgeWave resulting layer name generation - improved with adding the name of Dynamic component in case of the 4D volumes.

EdgeWave on near-isotropic lung volume "shifted-y-axis" defect:  was caused by slightly different definition of "isotropic" between different software modules.

Defect "View Projection of the Selected Entity": fixed defect when specifying projection produced an immediate crash.

FireVoxel Build 203 is released.
1. Corrected the defect when  .IM file is loaded that was missing the units info.
2. Fixed defect that presented itself as cropping failure.
3. Fixed: 3D Paintbrush, defects in Pint\Erase function on multiple projections:
4. "Deidentify DICOM folder" function:  fixed defect when the DICOM structure of resulting file set was lost after de-identification.
5. EdgeWave4D:  enabled functionality to process all of the timepoints of the 4D volume individually and to output a ROI-4D.

Volume Paintbrush:  relocated the code from FireVoxel.exe module to the platform-independent module: VolumeAnalyze.dll.

EdgeWave4D:  enabled functionality to process all of the timepoints of the 4D volume individually and to output a ROI-4D.

"Deidentify DICOM folder" function:  fixed defect when the DICOM structure of resulting file set was lost after de-identification.

3D Paintbrush, defects in Pint\Erase function on multiple projections:  fixed the issues expose by (1.2,1.2,4) mm volume.

Fixed defect that presented itself as cropping failure.  This was due to the fact the new cropped document was created without the full path, just the name. Corrected now.

Corrected the defect when  .IM file is loaded that was missing the units info.  Such units info was incorrectly loaded that was leading to incorrect save to .FVX file and further crash when that .FVX was loading.

FireVoxel Build 202 is released.

1. Corrected the 3D Paintbrush functionality for volume editing in 3 orthogonal projections.  Now the cursor and the result of the drawing are correctly updated in all projections.

2. Corrected the code responsible for recalling the state and the position of the window on the startup.

3. Histogram thresholding with BiGauss using Ratio:  algorithm was implemented.  The goal was to process the FGT-segmentation cases which were not processed by the Z-alg.

4. Bigauss with Ratio histogram split:  implemented the rebinning to a smaller #bins=128 to x10 speedup on  FGT segmentation.

5. Global Optimization Framework:  implemented major improvement to the algorithm that allows to reduce the number of candidates by x100.  In 6-dimension gaussian fit, after only 500K iterations this resulter in remaining parameters subspace of only 1e-14 of the original (by area).

6. User Interface  "Split ROI with Threshold" function:  Integrated the "BiGauss with Ratio" method to work seamlessly.

Re-enabled the ABT - Dynamic Framework subtest after the API calls for the Global Optimization were changed.

User Interface  "Split ROI with Threshold" function:  Integrated the "BiGauss with Ratio" method to work seamlessly.

Global Optimization Framework:  implemented major improvement to the algorithm that allows to reduce the number of candidates by x100.  In 6-dimension gaussian fit, after only 500K iterations this resulter in remaining parameters subspace of only 1e-14 of the original (by area).

Bigauss with Ratio histogram split:  implemented the rebinning to a smaller #bins=128 to x10 speedup on  FGT segmentation.

Histogram thresholding with BiGauss using Ratio:  algorithm was implemented.  The goal was to process the FGT-segmentation cases which were not processed by the Z-alg.

First doublechecked that in case of clear peaks the result is as good or close as Z-alg:

case ABRI:  BiGauss with ratio [2,4] finds good separation

Next we attempted to process harder cases where the peaks are much less clearly separated.  In all the experiments below, 10M iterations were used. User can now specify the amount of iterations required.

case ABBR: histogram split

case ABBR:  thresholding segmentation

case BARA: histogram split

case BARA: threshold seg,mentation

case BARZ

case BARZ: threshold segmentation

BiGauss histogram split: added the dialog box to specify Max Number of iterations.

Global optimization: added an optional progress bar.

Corrected the code responsible for recalling the state and the position of the window on the startup.

Corrected the 3D Paintbrush functionality for volume editing in 3 orthogonal projections.  Now the cursor and the result of the drawing are correctly updated in all projections.

Build 201A is released.

Fixed the defect when the ANALYZE file is loaded as the ROI layer and FireVoxel asks to specify modality even though the main volume already has the modality specified.
Extended the range of file extensions accepted under the "Load RAW" function.
Enabled the "sticky note" prompt for the 1st and last buttons of the main toolbar.
F11 - "Advance to next Landmark" function: corrected the defect so it changes to correct slice and landmark is now visible.

Fixed the defect when the ANALYZE file is loaded as the ROI layer and FireVoxel asks to specify modality even though the main volume already has the modality specified.
Extended the range of file extensions accepted under the "Load RAW" function.

Enabled the "sticky note" prompt for the 1st and last buttons of the main toolbar.

F11 - "Advance to next Landmark" function:  corrected the defect so it changes to correct slice and landmark is now visible.

FireVoxel Build 201 is released.

Reenabled ABT on all subtests.

"Deidentify DICOM folder": fully parallelized and optimized.

Implemented initial version of "Deidentify DICOM folder" User-level function

ABT: SaveDICOM subtest:  Fixed the defect that was introduced during the DICOM API changes during the FGT-segmentation project.

Layer Control Dialog>Load RAW:  enabled loading of the .NII files as a layer.

Global Optimization:  "BiGauss Histogram Split" cost function, changed the calculation arrangement to improve the speed of calculation\convergence about x2.  In interval math, the Square(A)/Square(B)  should be replaced instead with Square(A/B) for better convergence (A,B are intervals).

Global Optimization framework:  improved the memory handling so only a single generation is stored for one split iteration, reducing memory by x2

Improved reporting of Max Total and Max Block memory allocation.

Fixed the thread safety defect in MonoExponential fit function for Global optimization.

Fixed the parallel version of Global Optimization. Now all the Dynamic Framework subtests are checking out OK.

Dialog RoiStats3D: Added a histogram bin tracker feature.  User moves the mouse over the histogram and corresponding bin value and bin count are displayed.

Dialog RoiStats3D:  fixed the defect when the displayed histogram span was set with incompletely taking the ROI info into account.

Main Menu>ROI>Load Vector ROI function.  The last used directory is now remembered within the session. It is also saved into the configuration file between the sessions.

Layer Control dialog:  Implemented basic Copy\Paste volume operation to move the layers between documents.

Implemented and exposed GUI for the additional options of histogram thresholding. Global optimization framework:  full parallelism of the main loop.  This allow the application programmer not to bother with parallelizing the cost function thus greatly simplifying the usage.

Dual peak (bi-modal?) histograms:  implemented an initial version of algorithm that find an optimal representation of histogram as the sum of 2 gaussians.  Global optimization framework is used.

DicomTree load:  added extra diagnostics when composite series are present but some files are missing so the logical structure could not be constructed.

Mouse PET dynamic dataset (from Jean): latest version of FireVoxel loads it without problems as a dynamic  volume (33x26x26  with 48 timepoints)

Dialog RoiStats3D:  integrated algorithm selection tool  {Otsu,Zigalga} for segmenting the Histogram. Developed a prototype of a novel  Histogram  splitting algorithm, comparing to Otsu on the breast

Registration by DICOM-tags only.  Corrected the defect so that the Window\Level settings after the operation are exactly those of the source volume

DICOM loading of the files containing Rescale\Inrtercept information:  Improvement to user interface was done.  Even if the Rescale\Intercept are "trivial" (i.e.  1/0) we now ask the user if the volume has to be loaded as INTEGER or REAL.  In case of REAL user needs to specify additional offset\factor.
Pressing SHIFT button is NOT required anymore during the "Select by rectangular Net" function when mouse is dragged and selects all the objects within the rectangular area.

Change of the workflow for using the Window Level\Width tool.  User now has to press the new  Window Level\Width button on the Toolbar.  This puts FireVoxel into the "Window Level\Width" mode with the appropriate Mouse Cursor change.  Then user can change the Window Level\Width several time.  On Pressing ESC  the cursor changes back to "SELECT" mode. !Important:  This also fixes error when then  View Filter  Window Level was randomly changed after loading the Vector ROI.  This was happening because the Mouse Move command is sent after the closing the Open VROI file dialog.  This Mouse Move was erroneously interpreted as the request to change the Window Level\Width. 

RoiStats 3D could be applied to specified range of values in data. Specify "Value Interval [Start,End]" parameters.

Implemented fully functional version of Breast FGT measuring workflow.
Fixed the defects with the Status bar progress indicator in
VolChangeResolution and VolN3 functions.

Fixed defects with the progress status bar text messages while loading the FVX document.

MainMenu>Volume>Crop with 4D ROI- all layers.  "Enabled" flag is now copying correctly for all the layers in the entity.

Layer Control Dialog> Load DICOM :  now using current UserOptions.LoadDicomFolder settings.

MainMenu>ROI>List All VROIs function now displays the message  "No VROIs are present".

Provided an initial verison of the Breast FGT Batch processing dialog.

Reenabled ABT on all subtests.

"Deidentify DICOM folder": fully parallelized and optimized the processing reducing the time ffrom 40 min down to 4 min for 32,600 files.

Implemented initial version of "Deidentify DICOM folder" User-level function