Build 368A is released.

 1. Fixed the "Missing Block" defect when certain operations would stop with such message. This was due to "legalizing" NULL blocks in recent Builds when they represent a block filled entirely with VOID voxels.

Build 368 is released.

 1. Model 9 (Extended Tofts) :  added a hyperparameter for Minimal IF delay so the negative values could be used.

2. High speed up (x25 times )  of the IDIF function due to memory access re-arrangement.

Build 367 is released.

 1. Fixed crash defect : when attempting to create a REAL layer where all voxels are VOID.

2.  Fixed defect:  _isnan() function replace with _finite()

3. implement (optional) IDIF function working on the enhancement image. User has a choice

{Signal,Enchancement}

4.  Implemented IDIF dialog version : option for Input data {Signal,Enhancement}

5. Performed peformance optimization in FindMiniseed function (x2 speed improvement)

6. Added Progress indicator in FindMiniseed function that takes the majority of time.

Build 366A is released.

 1. Dynamic experiment dialog : Corrected item names to properly capitalize

2. Model #24: corrected the crash when residual layer was requested.

Build 366 is released.

 1. Dynamic parametric modelling : Made corrections in how Optimization Methods are handled. Added LLS method to the Model 24.

2. Deidentify DICOM folder : fixed defect when the files were deleted on repeated application of the procedure.

3. RoiStats3D UI function : Wait cursor is displayed so there is no perceived "hang" on larger images

4. Dynamic Modelling Global noise estimation : changed the algorithm to Diff2D.

5. Dynamic Model #24 (T1-mapping with Flip angle) : added a hyperparameter for the background expressed as the multiple of the Global Noise.

6. When F3 is pressed (on 3D image) hourglass or progress indicator  shows up. Otherwise for large volumes there was a long delay without the feedback.

7. Model 8:  Input function delay extended to the interval [Min,Max] so the negative delay (f.e. vein) could be used.

8. Set default HCT=0 in all locations except Dynamic Modelling Input Function.

9. Moved NLM-denoising to under MainMenu>Volume

Build 365B is released.

1. Dialog Concentration Conversion : when called from RoiStats4D dialog the "from DICOM" button had no effect. fixed now.

2. On the start of the Concentration Converison dialog : only the fields relevant to the starting Conversion method are enabled.

3. Fixed "Defect 12" report : from RoiStat4D dialog, the conflict between Copy To Clipboard and Save buttons when the whole concentration was turned to 0)

Build 365A is released.

 1. Dynamic Analysis>Convert 4D Volume to Concentration>Using T1-map  : Now the last dialog Concentration conversion settings are remembered between sessions.

2. Dynamic Analysis>Convert 4D Volume to Concentration>Using T1-map  : In Concentration conversion dialog the "from DICOM" button now works.

3. Concentration Conversion dialog:  fixed the defects when dialog entries would revert to their original values after pressing { LookUp Value, From DICOM}

Build 365 is released

 1. Model 24: corrected the formula appeared on the screen (no change to the code). T1-map output units are corrected to (sec)  from (ms)

2. Implemented UI-level function to construct a uniform REAL layer with specified signal and name.

This is under MainMenu>Volume>Construct Uniform layer.

3.  Implemented UI-level function to convert given 4D volume to 4D concentration volume using the voxel-wise T1-map.

 Build 364A is released.

1. Move the File>Open DICOM Series menu item to under  File>DICOM>Open selected SERIES.

Build 364 is released.

 1. Corrected various defects in the "Split Multiframe DICOM" function. Was able to load the provided CT-3D  and PET-4D files (500 and 3840 frames respectively).

2. "DICOMDIR to File Folders" : address several situations when the target folder is non-present or non-empty.  Source folder is now using the last value used for Open DICOM operation.

3. Remove "Open DICOM Series" from the main menu.

4. On the Main menu, replaced the "Open DICOM Volume...." with "Open DICOM folder..."

5. Fixed the defect, when 3D Roi is created over the 4D base volume, not able to draw. This was due to the incorrect calculation of spatial resolution (Vz=0)

6. Volume>Smooth : Enabled the floating point values for the Radius in the dialog (from INT)

7. Volume>Smooth: Corrected execution for when the source volume contains negative values.

8. Volume>Smooth (3D) : corrected so smoothing is available for REAL volumes including negative value.

9. Volume>Smooth menu item was changed to Volume>Smooth  over (optional) ROI.

Build 363A is released.

 1. Fixed a defect introduced in B363 (BlockMinMax). It was causing Signal-To-Screen Window Width to be 0.

2. Open DICOM dialog box > DELETE function : added a verify prompt to avoid accidental delete.

3. When adding a layer from file  {MIDAS,ANALYZE} and no orientation is present (VOID), there is no warning prompt and layer is seamelessly loaded.

4. Addressed a list of minor interface modifications requests.

5. Added to default PHI tags:  { OtherPatientIDs, OtherPatientIDsSequence }

Build 363 is released.

 1. REAL volumes : Upgraded internal 24-bit representation to the full REAL 64-bit representation.  Introduced new fast compression to address important situations : 

         a) Many VOIDVOX voxels

         b) REAL image was created using Nearest Neighbor scale up (f.e. in PET-MR registration            workflow).

2. Fixed a longterm defect in FrameSetBlock function when the Block buffer was improperly reallocated cutting 4 bytes off the buffer (unpredictable results in accessing uninitialized memory when displaying images),

 

3. Modified all ABT subtests to work with the new REAL representation

Build 362 is released.

 1. Added UI functionality to modify\insert b-values into SERIES or IMAGE items right from the DICOM Open dialog box.

2. Parametric Modelling dialog: fixed the error in re-creating the list of available models.

3. Parametric Modelling dialog: Implemented combo box an parameters to control optimizations.

4. Model DKI (#28) implemented the Simplex method in addition to current Global Optimization.

5. Updated and fixed the Dynamic Aggregation function (for the repeating dynamic coordinates). Provided a new ABT test for it.

6. ABT test implementation for Dynamic Aggregation.

7. Fixed the "hang" defect in Model28 while using Simplex.  Seems like hang is caused by the malloc (replaced by static buffer), which contradicts to malloc being advertised  as thread-safe.

8. Removed access to Model#12 (AATH) from the interface since it is not used and maintained at the moment.

9. Updated all dynamic models to remove the redundant optimization {GridN,Niter} parameters which are part of the standard optimization panel now.

10. Verified all the ABT subtests and regenerated new ones due to change in hyperparameters of most of the models.

 Build 361A is released

1. Cardiac Output correction dialog:  introduce CO precision parameter that controls the speed of the iterative optimization process.

2. Fixed the "time remaining" display in Cardiac Output correction processing.

3. FVX expiration date updated.

 Build 361:

1. Implemented 2 additional methods Cardiac Output-based IF correction

Build 360B is released.

 1. Volume Info dialog: displays now Transfer syntax and File Size.

2. Dialog RoiStats4D corrections:  Display extra 5% of space over the peak, show a bit more plotting area over the peak.  If Time is dynamic component it is display with no more than 2 decimals.

3. Dynamic Experiment single curve result dialog:  changed the Copy button to Report button that pops-up the Notepad and text document.

4. Dynamic Experiment single curve result dialog:  when press Report the text file contains the T1 information for each ROI present.

5. Fixed crash in  PCA-4D segmentation function

Build 360A is released.

 1. Include the message preventing saving REAL volumes to DICOM.

2. Resolve issue when the .NII.GZ file is loaded and trying to save back to .NII the .GZ extension was not recognized.

3. Dialog ROI Stats3D > Save Stats function : fixed defect in saving histogram when a void extra bin was saved at the end of histogram.

4. Dialog ROI Stats3D > Save Stats function  modified code so the the info save to a string and it writes to a file in a single write.

5. Dialog RoiStats3D : the X-axis range limits are displayed properly and are updated when they changed by User.

6. EdgeWaveLive:  fixed crash when multiple parameter changes are requested in a quick succession. This was due to the parallel nature of Windows interface so Processing was started within the existing Processing.

Build 360 is released.

1. Concentration Conversion dialog: for "No Conversion" method : disabled the Manual baseline mode,  disabled Contrast relaxivity field, enabled the HCT field. 

2. Concentration conversion method "SIGNAL" switch the interface name and source code to "No conversion" 

3. Parametric modelling Dialog:  Tissue Concentration Conversion Dialog:  HCT field is automatically set to zero and disabled (grayed).

4.   CO correction dialog: changed the naming of several fields to "Uncorrected"

5. FVX file format (v11):  now stores the Input Function Attributes, IF Concentration, Tissue Concentration settings of the current Dynamic Experiment.

6. Implemented Lookup Value button in the Concentration Conversion Dialog.  It activates the Contrast Relaxivity lookup reference table with the corresponding dialog.

7. Opening ".gz" image files  : fixed defect when either Source folder or FireVoxel folder contains spaces resulting in "File Not Found" error.

8.  Concentration Conversion dialog:  Attributes panel:  added the "from DICOM" button and corrected the behavior of Attribute fields upon saving and modelling.

9. DynamiAnalysis>CrossMutualInfo4D : Fixed crash and output appropriate diagnostics

10.  In Concentration Conversion dialog:  if this is not tissue the Two site water exchange model is disabled.

11. Updated the Model 7 (Inversion Recovery) and reconstructed the corresponding ABT subtest.

Build 359.

 1. Released first draft of FvxRad  documentation (Radiomics)

2. Radiomics 2D fixes related to VOIDVOX handling.

3. Fixed defect: when FireVoxelConfig file is empty the application crashes without starting.

4. MainMenu>ROI>Morph eliminated and subitems moved to under MainMenu>ROI>Morphology

 5. MainMenu>Register>AutoFocus with URAL removed.

6. FVX Document now have a proper "Modified" flag which is tacked correctly in all UI functions.

there was a

7. Dynamic experiment: when IF and Signal curve have different timelines, fixed mismatch between relative times for the IF curve and absolute times (since 1900) for the data curve.

 

8. Model (#8 Tofts)  exclude now all the timepoints before the contrast arrival.  This is done

by detecting first non-zero value in the modelled concentration curve.  Then residual is found starting

from that point

Build 358 is released.

 1. Radiomics output to text file is now formatted in scientific notation (1e-x)

2. Cardiac Output dialog : new option is to save the original curve in current selected concentration.

3. Extended Radiomics2D to have an option to process all the enabled (marked) ROIs at once.

4. Fixed problem when DlgRoiStat3D accessed from Radiomics2D dialog box, SaveStats function was different from one accessed directly through DlgRoiStats3D.

5. Corrected the displayed Model names for {17,18,21}

FireVoxel Build 357A is released.

 1. AIF Cardiac Output correction:  performed a fix during the iteration process which prevents a false Signal->Conc monotonity check failure.

2. AIF Cardiac Output correction:  Outputs "Time remaining" during the processing.

FireVoxel Build 357 is released.

 1.  Implemented the UserOptions option for Auto-retile document or new Views.  If unchecked,  the new View takes entire client area of the application.

2. In Parametric Modelling dialog: when Model is selected that allows only the Signal, the Tissue Concentration and IF Concentaction buttons are disabled\grayed.

3. Moved the {MagTrace,Rasterize} buttons of the main toolbar right after polyline button.

4. Implemented a notion of "VOID Image Orientation" for file formats or files when Orientation info is not present (f.e. MIDAS and sometimes ANALYZE).

5. Implemented UI function for "Set Volume Orientation".

6. Model 19: Fixed the RelPrecision error that was causing infinite loop.

    Models {7,16,17,18,44}: Removed the RelPrecision hyperparameter by setting it to default value.

7. Re-enabled Extrapolate Dynamic Dimension and made several improvements.

8. RoiStats3D dialog:   BinWidth and Range are displayed now in scientific (exponent) format.

9. Radimics dialog : changed Discretization display to scientific format.

10. Fixed : When calling Radiomics2D function with undefined discretization and setting it through RoiStats3D dialog the parameters were not properly transferred into the Radiomics function.

 Build 356 is released.

 1. MainMenu>File  :  implemented an additional function for loading DICOM files as SERIES, without constructing logical Volumes.

2. CO measurement and Correction tool : made available from the main menu under Dynamic Analysis

 

3. File>DICOM>Save Volume to Folders  option saves into the specified Folder but the files are sorted into subfolders by their respective SERIES.

4.  When DICOM Loading in "All checked items" mode additional checks for compatibility with the Volume such as {Orientation,  Slice Location} etc.

5. When Invalid FVX file contains DICOM header size=0, an appropriate diagnostics is displayed and the function orderly exits without crashing.

6.  Models {19,21,28}:   removed the Noise and RelPrecision parameters from the User Interface

7. Model {28} : Output Parameters and RMSE bounds after (global) optimization.

8. Enabled GO Solution Bounds in Monoexponential fitting.

      Model { 19,21} Output Parameters and RMSE bounds after (global) optimization.

9. Models {17,18,21} replaced the name of hyperparameter "Tail noise cutoff" with "Low signal tail cutoff"

Build 355C is released.

 1.  Save DICOM UI function (both the MainMenu>File and from LayerContol dialog) :  option pops up to generated all new random UIDs (SERIES, etc) or preserve the ones from original file.

2. DICOmM Deidentify function:   resulting files change the name to  image_XXX."original extension". Original files are deleted. Progress message now shows how many files are processed.

3.  Registration>Using Landmarks:   replaced the Affine Transform (which was previously done using Poly engine) with the explicit Affine optimization. 

Build 355B is released.

1. Made UI corrections in  Workflow>Rodent>Register to PET space.

2. CO correction tool:  fixed crash when no curve is loaded and user clicks on the plot area.

3. CO correction dialog : changed the dialog title. Removed the CLOSE (X) button which was causing the Stats notepad to show up and dialog would not close (Windows Bug?)

4.  MasterFilePresent checks avoids the expiration date check.  This allows to easily test old expired versions.

Build 355A is released.

 1. RoiStats3D dialog:  Histogram setting behavior change:

In Multilayer entity every layer volume (both Roi and Non-Roi) remember the range but keeps the track if ROI content is changed or the measure layer is different. Histogram parameters are now remembered within the ROI.

2.  FullRange button is enable only if the current range is not a FullRange.

Build 355 is released.
 

 

 1.  DICOM Tree to File Folders tool:  implemented the proper naming of Patient\Study\Series folders.

2. Verified correctness of the operation:   Load DICOM -> Save NIFTI ->Reload in the 3rd party package and display orientation correctly.  Checked out :  3D Slicer, MRIcron, ITK-SNAP all working correctly. Mango does not.

3. NIFTI load orientation:  added code for when sform>0 and qform=0. This fixes the NIFTI nih test dataset problem.

 

 

 

 

 

 

4. User Interface options dialog:

Corrected the "Posterior on Top" to "Anterior On Top"

 

 

 

5. Fixed PET-4D Dicom Load defect (mouse volumes with Non-isotropic pixel).

6. Introduced User option Projection View Convention {Original Data, Radiological, Neurological}.  This is a new option in the User Options dialog (replaces 2 previous options Right On Left }

 

 

 

 

 

 

 

 

7. WML lesion processing:  both Base2016 and V353 versions are exposed on the corresponding menu now. 

8. Fixed: When Layer Dialog box was open, after the parametric model ran it was not updated completely.  Presently, if "Process ROI only" mode isactivated the ROI is automatically disabled at the end so we can see the ParametricMap clearly. So Auto disable was not reflected in Layer Dialog.

 

9.  Model 29 (MRTM0):  changed the definition of   R₁ = −β₂/β₃.  to match the definition in Ichise paper here:  

https://journals.sagepub.com/doi/10.1097/01.WCB.0000085441.37552.CA?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&

Build 354B is released.

 1. Restored the preferential Zoom\Display for the primary (natural) projection with the proper slice scrolling, FilmView etc.

2. When loading the volumes with differing X-Y resolution immediately perform conversion to X=Y resolution.

3. Expiration date reset.

4.   Info crash  problem went away after #1   was fixed.

 1. Integrated DICOM JpegLS loseless codec. Verified loading with 3D Slicer

2. User Option dialog: DICOM compression clarified JpegLS information.

3. Added support function under File>DICOM>DICOM folder Total Pixel Element size so just

the pixel info can be measured during the compression evaluation.

 

Build 354A is released.

 

 1.  CO correction dialog : Stats :  added extra measurements to the notepad document.

2.  CO correction dialog : Save :  now save the currently selected (and displayed) concentration curve.

3. CO correction dialog : Enabled the color swatch for FPC curve

Build 354 is released.

 

 1.  White Matter Lesions detection: rolled back to the original H.2016 document  version.

2.  Remove preferential optimized display of volumes when in natural projection. This fixes the display of images with unequal X-Y resolution.

Build 353 is released.

 

 1. Cardiac Output correction dialog:  added the optional display of the First Pass Curve used for calculation of the AUC in CO.

2.Modified first pass curve so the starting segment before the first non-zero concentration is interpolated by gamma variate.

3. Provided a new variant of the Gamma variate fit which guarantees that the peak of GV exactly matches the peak of the original curve.

 4. Implemented Concentration->Signal conversion for T1WR1NLC concentration method. This is required.

 5. DICOM load: enabled loading of the DICOMs with 32-bit signed\unsigned internal representation. 

6. Cardiac Output Calculation and Correction dialog:

Separated the Esimate CO and Actual CO fields for clarity.

7.  Added Stats button to the CO dialog.

 

FireVoxel Build 353 is released.

 

 1. Cardiac Output dialog parameters are now remembered between dialog restarts.

2. Made correction to the Gamma Variate fit and added the Wait Cursor.

3. AutoFocus registration:  when the single Affine Grid transformation is considered(Translation only) then the progress bar is displayed.

4.  AutoFocus final transform: fixed defect when ROI layer is tranformed the Empty color (VOIDVOX32) was incorrect and causing the empty fields getting value 1.

5. Implemented a specialized function to Uncrop kidney volume to the original FOV including ROIs.

 

         a) Load both Cropped and FFOV documents. 

         b) In FFOV documents unmark all the layers except for the main (base) layer.

         c) In Cropped document unmark all the layers except for the main (base) layer and one significant               non-empty ROI (as in screenshot). 

         d) Make the Cropped document active.

         e) Go to MainMenu>Workflow>CERENE3D>Uncrop Volume command.

         f) Dialog box will appear with all parameters set.  The only parameter that might need changing                  in the future is the Translation X,Y,Z. Default 100mm was sufficient for this example.

         g) Press OK. After some processing all the Layers of Cropped document will be transferred to the             FFOV document.

        h) Result:

 

6. Updated the Cardiac Output-based Input function correction functionality. Added the Gamma Variate fit parameter

7.  When DICOM is loaded with trivial Slope\Intercept (1\0) verification dialog does not appear anymore.

FireVoxel Build 352 is released.

 

 1. Concentration conversion dialog : Updated the parameters in the Signal Baseline panel. Items are grayed if Manual parameter not checked.

2. Gamma variate fit upgrade: provided algorithm improvement to deal when signal starts after long delay.

This works in conjunction with Concentration conversion:

In HUANK case:

User specifies the initial phase:

Gamma variate fit is properly done by skipping specified points and looking for the optimal X0 now.

3.  Gamma Variate curve is now drawn with 0.1 sec steps for more intuitive viewing. Point markers are still shown in original time.

4. Cardiac Output correction dialog box:  when the curve is not loaded all the appropriate UI documents are grayed.

5. Cardiac Output dialog \ Attributes \  opened dialog now titled Blood attributes.

Build 351A is released.

 1. White Matter lesions detection: provided algorithm update for morhological closure of Brain Mask Base. Provided UI dialog field for updating the closure value in mm.

2. RoiStats3D dialog box: when only ROI layer is present the voxel and blob count is now calculated correctly.

3. IDIF function : fixed defect when Isotropic volumes are not processed.

Build 351 is released.

 1. Implemented initial variant of UI function:  DICOM Tree to Folders.

2. Fixed crash defect in RoiStats3D dialog:  when invoking the Zigalga-threshold. 

3. DICOM Tree to File Folders:  added handlers to when Source and Target folders do not exist,

when size of the free space in the Target folder is not sufficient.

 

FireVoxel 350 is released

 1.  DICOM Deidentification :  with the response from DCMTK forum a direct solution is now possible without creating the temp files.

2.  Fixed crash defect: DlgVROI activated, grayed out and after the document closing was crashing.

3. DICOM Deidentification tool now remembers the last used folder and suggests it.

4. Removed "Close All Document" and "Close Current Document" from the MainMenu>File because they also appear under MainMenu>View.

5. Introduced FireVoxelPHIprofile :  a text file should be residing in FireVoxel application directory that lists all the DICOM tags considered to be a PHI (Protected Health Information).

6. User can view current PHI Profile by choosing MainMenu>DICOM>Show PHI profile.

 Build 349 is released.

1. Replace the custom PR_FileCopy function with Windows-based CopyFile.

2.  Modified  "Deidentify DICOM folder" function to work "in-place". User only specifies a folder and files under the folder are modified when de-identified.

3. Under both Main menus moved all DICOM functions under File>DICOM

Build 348B is released.

 1. Model #27: fixed defect when for individual voxels the message would appear "not able to find a linear fit...".

Build 348A is released.

 1. Model #27 Logan Plot: Fixed the hyper parameter mix up defect.

Build 348 is released.

 

 1.  Added a warning when *.TIME file is loaded (either with .IM or NIFTI files) and dimensions specified in TIME header are different with ones in individual pixel files.

2. Modified model #27 Logan Plot was modified to better align with the description in PMOD documentation.

3. Modified Model #27 Vt (Logan Plot) to accept reference curves with the timeline different from the image file.

4. VROI dialog: when in "none selected" mode all the buttons are disabled to avoid various crash problems.

Build 347A is released.

 1. VROI dialog box: switch default units back to voxels.

2.  VROI dialog : Restored previous Z-coordinate convention.

3. VROI MainMenu>VROI>Delete All VROIs is now the only function for deletion.

4. VROI dialog box: the changes are preserved on cancel\close the dialog box.

5. VROI dialog box:  added the UNDO button.

6. List All VROIs command now shows a scrollable list of all present VROIs (previously just a plain message box).

Build 347 is released.

 1. Implemented Cardiac Output-based input function correction tool. Full UI dialog combined with Cardiac Output measurement tool.

2. VROI selected, VK_F4 opens the RoiStats4D dialog box. The curve is now displayed in color of the selected VROI (instead of fixed Green color).

3. VROI dialog: fixed defect pressing OK button would close dialog and never being able to open again.

4. VROI dialog both OK and CANCEL buttons are gone since they are redundant. You can close VROI dialog the same way as Layer Control dialog, i.e. by clicking the "exit" button

5. VROI file now contains the color attribute for each VROI.   Old VROI files are not supported.

6. Fixed defect in DICOM Tag registration when "Document with this name is present" was incorrectly appearing.

7. Replaced several 2 button question dialogs of type "Press Yes for X, press NO for Y" with the 3 button dialogs containing Cancel button.

8. VROI dialog box: replaced the mm\vox radio button switch with the combo box.

9. VROI dialog: fixed defect that for Z0,Z1 coordinates internal 0-based coordinates were displayed. Now they are 1-based as in User-convention and also matches the info displayed in the status line.

FireVoxel Build 346 is released.

 

 1. Provided a modeless (non-Modal) version of VROI dialog box. This way VROI dialog can stay open while we do all operations with VROI, including moving and browsing (F11).

2. Changed the Dynamic index convention from [0,Ti-1] -> [1,Ti] to match the other UI convention.

3. Changed the panel from Time to Dynamic Index 

 

 

4. Changed the diagnostics message when the FVX license file is missing.

5.  Show Main Toolbar command is now available from Main Menu when documents are opened.

6. Fixed the issues around the Insert Polyline (freehand) menu items.

7. Fixed defect in "Vector rasterize" when the previous content of the working ROI layer was overdrawn and disappeared.

8. Remove Mainframe>Test menu item from the Release versions.

9. Rasterization functions:  fixed Redraw problem due to parallel access of the ZoomCache.

FireVoxel Build 345E was released.

 1.  List all VROIs:  removed  "visible\invisible" status info.

2.  When VROI is created - it is assigned a default name  "vroi index", where index is the count

of VROIs previously created.

3. Moved VROI>3D to 4D to under MainMenu>ROI.

4. Moved VROI>Optimal zoom to  MainMenu>ROI>Zoom whole extent.

5. Fixed crash in Volume>Noise>Median Noise.

6. When ROI layer is created by any operation its DICOM headers are immediately and automatically minimized.

Build 345D is released.

 1. Corrected Gauss Downscale when the Single slice volume is transformed into single slice.

2. Restored the "diagonal cross" in VROIs, increased transparency.

3. "Create orthogonal projections"  : disallowed creating the repeating redundant projections.

4. In Multilayer entity, after removing one or more layers - the base layer becomes transparent.

 Build 345C is released.

 1. Transform>Volume Rotation dialog : Added the "Gaussian Downscale" option.

2.  Batch transform using task file:  replaced old interpolation radio buttons with common combo box.

3. Transform using VTF file dialog:  replaced old interpolation radio buttons with common combo box.

 

4. Fixed defect in BiCal batch processing:  when several subfolders of the Source folder were not processed.

 FireVoxel Build 345B

1.  Corrected the folder construction in BiCal Batch processing.

Build 345A is released.

1. Concentration conversion dialog\Relaxivity panel:  changed the order of dropdown boxes.

2. Mainframe Menu: Applications > Convert Tac to Concentration - introduce static Tissue Attribute so proper conversion is performed when next curve is loaded.

3. Upgraded the loading of Tac.txt files, so it allows the Title and the Format line.

4. BiCal batch function:   Target folder is required to exist and no attempt to create or clean the Target folder.

5. Cosmetic changes in Concentration Conversion dialog.

6. Concentration conversion: default HCT = 0.

7. PCA decomposition sets synthetic dynamic coordinates now with t=1,2,3,4,5

 Registered 4D CorDiff volume to the last timepoint (echo time) of GreCor volume. Last timepoint was chosen due to the highest contrast between the kidney and surrounding tissues.

Target kidney ROI first need to be constructed on the target (GreCor) either manually or automatically (manual in this example).  No ROI required on source (moving image).  However, registration relied on the fact that the volumes were acquired as part of the same exam so DICOM tags can be used for the initial alignment which is then finetuned by registration procedure.

Rigid registration was used in this example.  However, the volumes have very non-isotropic voxels

(1.5,1.5,7.5) mm, so the assumption of rigidity is very questionable and elastic deformation  may be used instead.

 

 

Optionally, the Target volume was made isotropic (1.5)mm^3.  This way the amount of information lost during the final reslicing is minimized.

Build 345 is released.

 

 1. Changed the automatic baseline calculation in the general Signal-to-Concentration conversion function.

2. Reduced internal MAX number of Input Functions to 4 (from 5). This was causing problems and crashes with displaying them, since the Dynamic Experiment dialog has only 4 slots.

3. Implemented the "Cardiac Output Measurement" tool and corresponding dialog.

 

 

 

 

3. Concentration conversion dialog:  implemented the 6--entry long relaxivity table using three dropdown combo boxes.

4. When saving to FVX file format, removed the DICOM tag PatientID from the list of PHI.

5.  Extended DICOM read to include the fix of files with deliimation errors. This resolves the load of the problematic PET file.

Build 344A is released.

 1. Implemented DICOM loader extension for files when the logical 3D volumes are intermingled along the time axis.

2. Added ABT subtest for DICOM "Intermingled-load".

 Prototype workflow for automatic whole kidney and compartamental segmentation on GRE data.

1.  Atlas of the kidney was constructed manually from the Patient (id  PP506).  Last TE timepoint (=30.53 ms) was choosen where the contrast between kidney and surrounding tissue is the maximum

2.  Another patient ( RH.41.L)  GRE dataset was chosen for segmentation.  At the moment we ask User to enclose the kidney with the bounding box in the mid-slice. Again the last TE timepoint (39.36 ms) was chosen to maximize the contrast between kidney and surroundings.

 

 

3. Internally full 3D bounding box is constructed which encloses the kidney.

 

4. We activate Large Deformation registration of the Atlas into the rough bounding box of the kidney.

 

 

 

5. After registration runs we get the Whole kidney mask and {Cortex,Medulla} masks over the 2nd patient. Note: the target volume was resliced to isotropic 2.08mm^3  to minimize data loss during the reslicing (since the Z-resolution is very coarse 5mm).

 

 

6.  Same result as above but displayed without Cortex mask.

7. Future improvements:  have better higher resolution Atlas, perhaps even from different protocol.

Have several atlases, match to all and select the best.

Alternatively, only the Whole kidney mask can be registered and then Whole mask can be separated into Cortex and Medulla.  Histogram thresholding is typically not working well for that purpose, so more locally adaptive operator should be used.

8 Below is one such result.  Whole kidney mask was taken from the result above, but then we used Detect Dark Ridges (default parms) to split the Medulla and the remainder is Cortex.

 Kidney registration from pCASL data to GRE data.  Last TE point of GRE was selected to draw ROI due to a better contrast with surrounding tissues. Then pCASL was registered using initial DICOM tag alignment with further Rigid registration using Mutual Info.

Each kidney has to be done separately at the moment, but a single click workflow for both kidneys is possible.

Three screenshot below demonstrate reegistration results:

a) GRE  ROI overlaid on top of the registed pCASL volume.

 

b) pCASL (in green) overlaid transparently over GRE (red)

c) Separately, GRE was turned into isotropic  2.08 mm^3 to minimize pCASL information loss during reslicing, then same registration was performed.

Build 344 is released.

  1. FLEXR3D registration : fixed defect in final layer construction was causing a crash.

2. Fixed the "invalid units" defect when output ADC model mm^2/sec. Now displayed properly.

3. Implemented functions for swapping Transparent (VOID) value <-> User Specified value.

4. Fixed defect: Volume Redraw cache  was relying on a simplistic CheckSum algorithm which sometimes return incorrectly TRUE causing the document Window not to redraw after the operation. Improved the CheckSum function, so old defects are properly redrawn.

5. Model #16  "T2 and T2* mapping":  changed name, some unit options etc.

6. Volume>Crop Current Slice : upgraded function to crop all existing slices. Reused the common code VolCrop function.

 7.   Chest Area  Muscle\FAT measurement: fixed defect "instead of MAT, 343A repeats the fat volume."

 8. Fixed defect when adding new layer (such as ROI) was producing incorrect Vz resolution for the new Layer. This was causing frequent "Resolution mismatch" messages.

9. Fixed the Colormap collapse problem when Color Window Width is set to 1.