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Wednesday, February 5, 2014

Calculated the Hepatic Uptake rate (Ki) for 2 patients. This is a very early and preliminary result.  Both maps use the same color scale. The units of measurement are "1/100/min" as per Sourbron's paper.


Implemented derived parameters as per Sourbron's paper.
Primary optimization parameters are Fa,Fv,Ve,Ki.
So far there was no need for the "Arterial Delay" as Henry had foreseen.


Performed DCDI calculation for two patients LP and KA.  Below are the "Total Inflow" maps (=Fa+Fv).  Color mapping is using the same color scale (see color bar on the right)


Liver DCDI modelling function is fast enough to process large ROIs on the voxel-wise basis
Below is the parametric map Arterial Flow (Fa) in  "ml/min/100ml" units as in Sourbron's paper.
Total calculation time is about 3 sec.


Liver DCDI model: 
a) Fully parallelized the "Grid search" preceding the iterative Amoeba  (Simplex) optimization
b) Integrated the Parallel Amoeba variant
Obtained first fitting result for the Liver DCDI model (Sourbron).
In this example 2 input functions are shown in Signal intensity units.
The target ROI is in red.
Fitted Concentration Curve (black) is overlaid on top of the Data Concentration Curve.
Optimal parameter values are shown at the bottom of the diagram. They are normalized
to Sourbron's unit from the paper and on a quick comparison are of the same order of magnitude.
Note:  Arterial delay of "0" was used.



Running tests of the Liver DCDI model, debugging and targeting the visualization of the model fit as the next waypoint.